Initial evidence of abnormal brain plasticity in anorexia nervosa: an ultra-high field study.
Initial evidence of abnormal brain plasticity in anorexia nervosa: an ultra-high field study.
复制标题
DOI：
10.1038/s41598-022-06113-x
复制
发表时间：
2022-02-16
影响因子：
4.6
通讯作者：
Micali N
中科院分区：
文献类型：
--
作者：
Pappaianni E;Borsarini B;Doucet GE;Hochman A;Frangou S;Micali N
神经性厌食症与涉及皮质下髓鞘形成异常的白色物质异常有关。将这些发现扩展到皮质内髓鞘具有挑战性，但超高场神经成像提供了新的方法学机会。为了测试AN中皮质内髓鞘的完整性，我们使用7 T神经成像来获取针对来自七名患有AN的女性（年龄范围：18-33）和11名健康女性（年龄范围：23-32）的皮质内髓鞘优化的T1加权图像。皮质内T1值（髓鞘浓度的倒数指数）从148个皮质区域在10个深度水平的整个皮质带提取。在所有皮质区域，这些水平被平均以产生总皮质内髓鞘浓度的估计值，并使用主成分分析聚类成两个簇;外部聚类包括从CSF边界到皮层区域中间的深度级上的T1值，内部聚类包括从皮层区域中间到灰度/灰度级上的深度级上的T1值。白色物质边界。患有AN的个体表现出较高的T1值（即，皮质内髓鞘浓度降低）。这些异常是否由营养不良或特定脂质营养失衡引起，或者是性状标志物，以及它们是否可能导致AN中的神经生物学缺陷，仍有待确定。
Anorexia Nervosa has been associated with white matter abnormalities implicating subcortical abnormal myelination. Extending these findings to intracortical myelin has been challenging but ultra-high field neuroimaging offers new methodological opportunities. To test the integrity of intracortical myelin in AN we used 7 T neuroimaging to acquire T1-weighted images optimized for intracortical myelin from seven females with AN (age range: 18–33) and 11 healthy females (age range: 23–32). Intracortical T1 values (inverse index of myelin concentration) were extracted from 148 cortical regions at ten depth-levels across the cortical ribbon. Across all cortical regions, these levels were averaged to generate estimates of total intracortical myelin concentration and were clustered using principal component analyses into two clusters; the outer cluster comprised T1 values across depth-levels ranging from the CSF boundary to the middle of the cortical regions and the inner cluster comprised T1 values across depth-levels ranging from the middle of the cortical regions to the gray/white matter boundary. Individuals with AN exhibited higher T1 values (i.e., decreased intracortical myelin concentration) in all three metrics. It remains to be established if these abnormalities result from undernutrition or specific lipid nutritional imbalances, or are trait markers; and whether they may contribute to neurobiological deficits seen in AN.
登录
查看更多内容
影响因子：
4.5
作者：
Bartzokis, George;Lu, Po H.;Stewart, Stephanie B.;Oluwadara, Bolanle;Lucas, Andrew J.;Pantages, Joanna;Pratt, Erika;Sherin, Jonathan E.;Altshuler, Lori L.;Mintz, Jim;Gitlin, Michael J.;Subotnik, Kenneth L.;Nuechterlein, Keith H.
通讯作者：
Nuechterlein, Keith H.
影响因子：
1.7
作者：
Kanakam, Natalie;Treasure, Janet
通讯作者：
Treasure, Janet
影响因子：
5.7
作者：
Dinse, J.;Haertwich, N.;Bazin, P. -L.
通讯作者：
Bazin, P. -L.
神经科学。髓磷脂 - 比绝缘材料。
DOI：
10.1126/science.1253851
发表时间：
2014-04-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Fields RD
通讯作者：
Fields RD
影响因子：
4.5
作者：
Bartzokis G;Lu PH;Raven EP;Amar CP;Detore NR;Couvrette AJ;Mintz J;Ventura J;Casaus LR;Luo JS;Subotnik KL;Nuechterlein KH
通讯作者：
Nuechterlein KH