In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophrenia.
In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophrenia.
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DOI：
10.1016/j.schres.2009.06.014
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发表时间：
2009-09
影响因子：
4.5
通讯作者：
Nuechterlein, Keith H.
中科院分区：
文献类型：
--
作者：
Bartzokis, George;Lu, Po H.;Stewart, Stephanie B.;Oluwadara, Bolanle;Lucas, Andrew J.;Pantages, Joanna;Pratt, Erika;Sherin, Jonathan E.;Altshuler, Lori L.;Mintz, Jim;Gitlin, Michael J.;Subotnik, Kenneth L.;Nuechterlein, Keith H.
关键词：
影像学和死后研究提供了越来越多的证据，表明精神分裂症患者的额叶髓鞘形成发育轨迹失调。典型和非典型药物可能对成年精神分裂症患者的脑髓鞘形成产生不同的影响，这一假设先前通过倒置恢复（IR）图像进行了评估。与典型抗精神病药物治疗组相比，非典型抗精神病药物治疗组检测到白质（WM）体积增加，提示髓鞘形成增加。在对原始研究的MRI图像的后续再分析中，我们使用了一种新的方法来评估WM体积的差异是否可能是由药物对皮质内髓鞘形成过程的不同影响引起的。将年龄在18-35岁之间的两组不同的健康对照男性与接受口服利培酮（Ris）或癸酸氟非那嗪（Fd）治疗的精神分裂症患者进行比较。一种新的MRI方法结合了由IR和质子密度（PD）图像提供的不同组织对比，用于估计皮质髓鞘（ICM）体积。与合并健康对照组相比，两组精神分裂症患者在额叶ICM测量上存在差异，Ris组的体积明显更高。这些数据表明，在精神分裂症成人患者中，抗精神病药物的选择可能会特异性和差异性地影响髓鞘形成后的皮质内回路。体内MRI可用于解剖脑组织特征的细微差异，从而有助于阐明药物治疗对发育和病理过程的影响。
Imaging and post-mortem studies provide converging evidence that patients with schizophrenia have a dysregulated developmental trajectory of frontal lobe myelination. The hypothesis that typical and atypical medications may differentially impact brain myelination in adults with schizophrenia was previously assessed with inversion recovery (IR) images. Increased white matter (WM) volume suggestive of increased myelination was detected in the patient group treated with an atypical antipsychotic compared to a typical one. In a follow-up reanalysis of MRI images from the original study, we used a novel method to assess whether the difference in WM volumes could be caused by a differential effect of medications on the intracortical myelination process. Two different male cohorts of healthy controls ranging in age from 18–35 years were compared to cohorts of subjects with schizophrenia who were treated with either oral risperidone (Ris) or fluphenazine decanoate (Fd). A novel MRI method that combines the distinct tissue contrasts provided by IR and proton density (PD) images was used to estimate intracortical myelin (ICM) volume. When compared with their pooled healthy control comparison group, the two groups of schizophrenic patients differed in the frontal lobe ICM measure with the Ris group having significantly higher volume. The data suggest that in adults with schizophrenia antipsychotic treatment choice may be specifically and differentially impacting later-myelinating intracortical circuitry. In vivo MRI can be used to dissect subtle differences in brain tissue characteristics and thus help clarify the effect of pharmacologic treatments on developmental and pathologic processes.
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影响因子：
10.6
作者：
Bartzokis, G;Nuechterlein, KH;Mintz, J
通讯作者：
Mintz, J
DOI：
10.1177/070674370104600906
发表时间：
2001-11-01
影响因子：
4
作者：
Baptista, T;Lacruz, A;Hernàndez, L
通讯作者：
Hernàndez, L
影响因子：
--
作者：
Bartzokis, G;Beckson, M;Mintz, J
通讯作者：
Mintz, J
影响因子：
10.6
作者：
Bartzokis, G;Lu, PH;Saunders, CS
通讯作者：
Saunders, CS
影响因子：
4.2
作者：
Bartzokis, G;Sultzer, D;Cummings, JL
通讯作者：
Cummings, JL