Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review.
Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review.
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DOI：
10.1007/s11523-017-0546-x
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发表时间：
2018-03
影响因子：
5.4
通讯作者：
Albany C
中科院分区：
文献类型：
--
作者：
Chovanec M;Taza F;Kalra M;Hahn N;Nephew KP;Spinella MJ;Albany C
抑制DNA甲基转移酶（DNMT）已成为实体瘤的一种新的治疗策略。关键肿瘤抑制基因启动子中的异常高甲基化是低甲基化剂治疗可能导致“正常”表观基因组恢复并产生临床有意义的治疗结果的想法的基础。这篇综述文章的目的是总结DNMT抑制剂治疗泌尿生殖系统恶性肿瘤的知识现状。这些药物在泌尿生殖系统恶性肿瘤中的疗效在许多研究中有报道，并表明诱导DNA低甲基化在克服对常规细胞毒性治疗的耐药性中的作用。这些发现的临床意义应进一步研究。
Inhibition of DNA methyltransferases (DNMTs) has emerged as a novel treatment strategy in solid tumors. Aberrant hyperme-thylation in promoters of critical tumor suppressor genes is the basis for the idea that treatment with hypomethylating agents may lead to the restoration of a “normal” epigenome and produce clinically meaningful therapeutic outcomes. The aim of this review article is to summarize the current state of knowledge of DNMT inhibitors in the treatment of genitourinary malignancies. The efficacy of these agents in genitourinary malignancies was reported in a number of studies and suggests a role of induced DNA hypomethylation in overcoming resistance to conventional cytotoxic treatments. The clinical significance of these findings should be further investigated.
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影响因子：
--
作者：
Albany C;Hever-Jardine MP;von Herrmann KM;Yim CY;Tam J;Warzecha JM;Shin L;Bock SE;Curran BS;Chaudhry AS;Kim F;Sandusky GE;Taverna P;Freemantle SJ;Christensen BC;Einhorn LH;Spinella MJ
通讯作者：
Spinella MJ
影响因子：
17.1
作者：
Andersen JB;Factor VM;Marquardt JU;Raggi C;Lee YH;Seo D;Conner EA;Thorgeirsson SS
通讯作者：
Thorgeirsson SS
影响因子：
7.2
作者：
Becker, Peter B.;Workman, Jerry L.
通讯作者：
Workman, Jerry L.
影响因子：
7.3
作者：
Choi, Won Jun;Chung, Hwa-Jin;Jeong, Lak Shin
通讯作者：
Jeong, Lak Shin
影响因子：
50.5
作者：
Candelaria, M.;Gallardo-Rincon, D.;Duenas-Gonzalez, A.
通讯作者：
Duenas-Gonzalez, A.