Induced and natural regulatory T cells in human cancer.
Induced and natural regulatory T cells in human cancer.
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DOI：
10.1517/14712598.2012.707184
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发表时间：
2012-10
影响因子：
4.6
通讯作者：
Schilling B
中科院分区：
文献类型：
--
作者：
Whiteside TL;Schuler P;Schilling B
有证据表明，FOXP3+CD25highCD4+调节性T细胞（Treg）在癌症中的积累可能对预后有有利或不利的影响。在肿瘤相关的炎性浸润中存在两个具有不同表型和功能特征的Treg亚群可能解释这些相互矛盾的观察结果。由肿瘤驱动的常规CD4+ T细胞转化产生的人诱导性（i）Treg是高度抑制性的、治疗抗性Treg，其下调抗肿瘤免疫应答，促进肿瘤生长。天然（n）Treg通常负责维持外周耐受性，控制癌症相关炎症，这有利于肿瘤进展。nTreg和iTreg之间的这种分工不是绝对的，并且重叠可能是常见的。然而，iTreg在癌症和癌症治疗中起着关键和主要的作用。肿瘤微环境决定了聚集Treg的类型、频率和抑制水平。在癌症中，选择性去除或沉默iTreg而不是nTreg应该是治疗目标。然而，这一具有挑战性的策略的实施需要进一步研究肿瘤微环境中免疫细胞之间的细胞和分子串扰。
Evidence suggests that FOXP3+CD25highCD4+ regulatory T cells (Treg) which accumulate in cancer may have beneficial or unfavorable effects on prognosis. The presence in tumor-associated inflammatory infiltrates of two subsets of Treg with distinct phenotypic and functional profiles might explain these conflicting observations. Human inducible (i) Treg arising by tumor-driven conversion of conventional CD4+ T cells are highly suppressive, therapy-resistant Treg which down-regulate anti-tumor immune responses, promoting tumor growth. Natural (n) Treg, normally responsible for maintaining peripheral tolerance, control cancer-associated inflammation, which favors tumor progression. This division of labor between nTreg and iTreg is not absolute, and overlap may be common. Nevertheless, iTreg play a critical and major role in cancer and cancer therapy. The tumor microenvironment determines the type, frequency and suppression levels of accumulating Treg. In cancer, a selective removal or silencing of iTreg and not of nTreg should be a therapeutic goal. However, the implementation of this challenging strategy requires further studies of cellular and molecular crosstalk among immune cells in the tumor microenvironment.
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募集高危险性CD8（+）T细胞的潜在池募集到抗肿瘤免疫反应中。
DOI：
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发表时间：
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期刊：
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影响因子：
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