Obesity, inflammation, and liver cancer.
Obesity, inflammation, and liver cancer.
复制标题
肥胖、炎症和肝癌。
DOI：
10.1016/j.jhep.2011.09.020
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发表时间：
2012-03
影响因子：
25.7
通讯作者：
Karin, Michael
中科院分区：
文献类型：
--
作者：
Sun, Beicheng;Karin, Michael
肥胖症已成为一个普遍和主要的公共卫生问题，在21世纪的成人和儿童中的流行率越来越高，即使在发展中国家。广泛的流行病学研究揭示了肥胖与各种癌症的发展和进展之间的密切联系。肥胖和肝癌之间的联系特别强，肥胖经常导致肝脏疾病，如非酒精性脂肪性肝病（NAFLD）和更严重的非酒精性脂肪性肝炎（NASH）。NASH的特征在于脂肪肝炎症，并被认为会导致纤维化和肝硬化。后者是已知的肝癌风险因素。事实上，由于其更高的患病率，肥胖可能是一个更实质性的贡献，整体肝细胞癌负担比感染肝炎病毒。在这里，我们回顾和讨论最近的进展，阐明细胞和分子的变化和信号通路与肥胖和肝脏炎症，以及它们的贡献肝癌发生。
Obesity has become a universal and major public health problem with increasing prevalence in both adults and children in the 21st century, even in developing countries. Extensive epidemiological studies reveal a strong link between obesity and development and progression of various types of cancers. The connection between obesity and liver cancer is particularly strong and obesity often results in liver diseases such as non-alcoholic fatty liver disease (NAFLD) and the more severe non-alcoholic steatohepatitis (NASH). NASH is characterized by fatty liver inflammation and is believed to cause fibrosis and cirrhosis. The latter is a known liver cancer risk factor. In fact, due to its much higher prevalence, obesity may be a more substantial contributor to overall hepatocellular carcinoma burden than infection with hepatitis viruses. Here we review and discuss recent advances in elucidation of cellular and molecular alterations and signaling pathways associated with obesity and liver inflammation, and their contribution to hepatocarcinogenesis.
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影响因子：
82.9
作者：
Arkan, MC;Hevener, AL;Karin, M
通讯作者：
Karin, M
AMP激活的蛋白激酶对ULK1（HATG1）的磷酸化将能量传感连接到线粒体。
DOI：
10.1126/science.1196371
发表时间：
2011-01-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Egan DF;Shackelford DB;Mihaylova MM;Gelino S;Kohnz RA;Mair W;Vasquez DS;Joshi A;Gwinn DM;Taylor R;Asara JM;Fitzpatrick J;Dillin A;Viollet B;Kundu M;Hansen M;Shaw RJ
通讯作者：
Shaw RJ
影响因子：
--
作者：
Bernstein, LE;Berry, J;Grinspoon, SK
通讯作者：
Grinspoon, SK
影响因子：
13
作者：
Ahmed, Mushtaq;Gaffen, Sarah L.
通讯作者：
Gaffen, Sarah L.
DOI：
10.1038/oby.2003.147
发表时间：
2003-09-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Asayama, K;Hayashibe, H;Taniyama, M
通讯作者：
Taniyama, M