Endothelin: a new inhibitor of renin release.

Endothelin: a new inhibitor of renin release.
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内皮素:一种新的肾素释放抑制剂。

DOI:
10.1016/s0006-291x(88)80996-3
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发表时间:
1988
影响因子:
3.1
通讯作者:
Shigeru Yagi
Shigeru Yagi
中科院分区:
生物学4区
文献类型:
--
作者:
Masao Takagi;Hiroaki Matsuoka;K. Atarashi;Shigeru Yagi

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内皮素是最近发现的一种血管收缩肽,由内皮细胞产生,作用于血管平滑肌细胞。目前其对其他器官或细胞的作用尚不清楚。我们研究了分散的大鼠肾小球旁 (JG) 细胞的动态灌注系统中内皮素对肾素释放的影响。浓度为 10−11M 或更高的内皮素会剂量依赖性地抑制肾素释放,并且这种抑制作用在没有细胞外 Ca 的情况下消失。提示内皮素是 JG 细胞分泌肾素的抑制调节剂,其作用是 Ca 依赖性的。
Endothelin is a recently-discovered vasoconstrictor peptide which is produced by endothelium and acts on vascular smooth muscle cells. At present its actions on other organs or cells are unknown. We studied the effect of endothelin on renin release in a dynamic superfusion system of dispersed rat juxtaglomerular (JG) cells. Endothelin in concentrations of 10−11M or more inhibited renin release dose-dependently and this inhibitory action vanished in the absence of extracellular Ca. It is suggested that endothelin is an inhibitory regulator of renin secretion from JG cells and its action is Ca-dependent.
肾素释放的细胞机制。
DOI: 10.1080/07300077.1988.11878910
发表时间: 1988
期刊: Clinical and experimental hypertension. Part A, Theory and practice
影响因子: --
作者:
Churchill,PC
通讯作者: Churchill,PC
心钠素对肾切片和分散的肾小球旁细胞灌注系统中肾素释放的影响。
DOI: 10.1210/endo-122-4-1437
发表时间: 1988
期刊: Endocrinology
影响因子: 4.8
作者:
Takagi,M;Takagi,M;Franco-Saenz,R;Mulrow,PJ
通讯作者: Mulrow,PJ
腺苷在兔肾素释放的致密斑机制中的可能作用。
DOI: 10.1172/jci112118
发表时间: 1985
期刊: The Journal of clinical investigation
影响因子: --
作者:
Itoh,S;Carretero,OA;Murray,RD
通讯作者: Murray,RD