Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study.
Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study.
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DOI：
10.1186/1471-2458-11-786
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发表时间：
2011-10-11
影响因子：
4.5
通讯作者：
Russo C
中科院分区：
文献类型：
--
作者：
Polosa R;Caponnetto P;Morjaria JB;Papale G;Campagna D;Russo C
吸烟是一种坚韧戒掉的瘾。因此，改进戒烟方法是必要的。电子烟（e-Cigarette）是一种类似香烟的电池供电电子尼古丁输送装置（ENDD），可以帮助吸烟者在戒烟过程中保持禁欲或减少香烟消费。尚未研究这些器械在长期戒烟和/或减少吸烟研究中的有效性和安全性。在这项前瞻性概念验证研究中，我们监测了40名经常吸烟者（不愿意戒烟）的吸烟习惯可能发生的变化，他们尝试了“类别”电子烟，重点是减少吸烟和戒烟。研究参与者被邀请参加总共5次研究访视：基线、第4周、第8周、第12周和第24周。在每次访视时测量产品使用、吸烟数量和呼出的一氧化碳（eCO）水平。计算吸烟减少率和戒烟率。还审查了不良事件和产品偏好。在第24周，13/40（32.5%）的参与者的吸烟次数持续减少50%;他们的中位数从25支/天减少到6支/天（p < 0.001）。在5/40（12.5%）的参与者中显示持续减少80%;他们的中位数从30支/天减少到3支/天（p = 0.043）。在9/40（22.5%）的参与者中观察到了第24周的持续戒烟，其中6/9在研究结束时仍在使用电子烟。在22/40（55%）的参与者中显示出持续减少50%和戒烟，每天吸烟量总体下降88%。口腔（20.6%）和咽喉（32.4%）刺激和干咳（32.4%）是常见的，但到第24周时显著减少。总体而言，整个研究期间每天使用2 - 3个笔芯。参与者对产品的感知和接受程度良好。电子烟的使用大大减少了卷烟消费，而不会对不打算戒烟的吸烟者造成显著的副作用（http：ClinicalTrials.gov编号NCT 01195597）。
Cigarette smoking is a tough addiction to break. Therefore, improved approaches to smoking cessation are necessary. The electronic-cigarette (e-Cigarette), a battery-powered electronic nicotine delivery device (ENDD) resembling a cigarette, may help smokers to remain abstinent during their quit attempt or to reduce cigarette consumption. Efficacy and safety of these devices in long-term smoking cessation and/or smoking reduction studies have never been investigated. In this prospective proof-of-concept study we monitored possible modifications in smoking habits of 40 regular smokers (unwilling to quit) experimenting the 'Categoria' e-Cigarette with a focus on smoking reduction and smoking abstinence. Study participants were invited to attend a total of five study visits: at baseline, week-4, week-8, week-12 and week-24. Product use, number of cigarettes smoked, and exhaled carbon monoxide (eCO) levels were measured at each visit. Smoking reduction and abstinence rates were calculated. Adverse events and product preferences were also reviewed. Sustained 50% reduction in the number of cig/day at week-24 was shown in 13/40(32.5%) participants; their median of 25 cigs/day decreasing to 6 cigs/day (p < 0.001). Sustained 80% reduction was shown in 5/40(12.5%) participants; their median of 30 cigs/day decreasing to 3 cigs/day (p = 0.043). Sustained smoking abstinence at week-24 was observed in 9/40(22.5%) participants, with 6/9 still using the e-Cigarette by the end of the study. Combined sustained 50% reduction and smoking abstinence was shown in 22/40 (55%) participants, with an overall 88% fall in cigs/day. Mouth (20.6%) and throat (32.4%) irritation, and dry cough (32.4%) were common, but diminished substantially by week-24. Overall, 2 to 3 cartridges/day were used throughout the study. Participants' perception and acceptance of the product was good. The use of e-Cigarette substantially decreased cigarette consumption without causing significant side effects in smokers not intending to quit (http://ClinicalTrials.gov number NCT01195597).
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影响因子：
37.8
作者：
Lightwood, JM;Glantz, SA
通讯作者：
Glantz, SA
影响因子：
9.6
作者：
Hatsukami, DK;Kotlyar, M;Murphy, S
通讯作者：
Murphy, S
影响因子：
5.2
作者：
Bullen, C.;McRobbie, H.;Laugesen, M.
通讯作者：
Laugesen, M.
用于评估电子“香烟”急性影响的临床实验室模型：尼古丁输送曲线以及心血管和主观影响。
影响因子：
3.8
作者：
Vansickel, Andrea R.;Cobb, Caroline O.;Weaver, Michael F.;Eissenberg, Thomas E.
通讯作者：
Eissenberg, Thomas E.
影响因子：
--
作者：
Smith, Stevens S.;McCarthy, Danielle E.;Jackson, Thomas C.
通讯作者：
Jackson, Thomas C.