Two insulin-like peptides differentially regulate malaria parasite infection in the mosquito through effects on intermediary metabolism.
Two insulin-like peptides differentially regulate malaria parasite infection in the mosquito through effects on intermediary metabolism.
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两种胰岛素样肽通过影响中间代谢来差异调节蚊子中的疟疾寄生虫感染。
DOI：
10.1042/bcj20160271
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Luckhart,Shirley
中科院分区：
文献类型：
--
作者：
Pietri,JoseE;Pakpour,Nazzy;Napoli,Eleonora;Song,Gyu;Pietri,Eduardo;Potts,Rashaun;Cheung,KongW;Walker,Gregory;Riehle,MichaelA;Starcevich,Hannah;Giulivi,Cecilia;Lewis,EdwinE;Luckhart,Shirley
Insulin-like peptides (ILPs) play important roles in growth and metabolic homeostasis, but have also emerged as key regulators of stress responses and immunity in a variety of vertebrates and invertebrates. Furthermore, a growing literature suggests that insulin signaling-dependent metabolic provisioning can influence host responses to infection and affect infection outcomes. In line with these studies, we previously showed that knockdown of either of two closely related, infection-induced ILPs, ILP3 and ILP4, in the mosquitoAnopheles stephensidecreased infection with the human malaria parasitePlasmodium falciparumthrough kinetically distinct effects on parasite death. However, the precise mechanisms by which ILP3 and ILP4 control the response to infection remained unknown. To address this knowledge gap, we used a complementary approach of direct ILP supplementation into the blood meal to further define ILP-specific effects on mosquito biology and parasite infection. Notably, we observed that feeding resulted in differential effects of ILP3 and ILP4 on blood-feeding behavior andP. falciparumdevelopment. These effects depended on ILP-specific regulation of intermediary metabolism in the mosquito midgut, suggesting a major contribution of ILP-dependent metabolic shifts to the regulation of infection resistance and parasite transmission. Accordingly, our data implicate endogenous ILP signaling in balancing intermediary metabolism for the host response to infection, affirming this emerging tenet in host–pathogen interactions with novel insights from a system of significant public health importance.
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不同品系大鼠对营养性白内障的易感性。
DOI：
--
发表时间：
1936
期刊：
影响因子：
--
作者：
H. Mitchell,
通讯作者：
H. Mitchell,
糖尿病性白内障——醛糖还原酶重要吗？
DOI：
--
发表时间：
1981
期刊：
Metabolic and pediatric ophthalmology
影响因子：
--
作者：
M. Crabbe;S. Wolff;A. B. Halder;H. Ting
通讯作者：
H. Ting
雄性大鼠从青春期前到高龄血清雄激素、雌激素、孕激素、促性腺激素和催乳素水平的变化。
影响因子：
1.8
作者：
S. Saksena;I. Lau
通讯作者：
I. Lau
犬视网膜微血管产生己糖醇。
影响因子：
4.4
作者：
Kern,TS;Engerman,RL
通讯作者：
Engerman,RL
影响因子：
56.9
作者：
DVORNIK, D;SIMARDDU.N;MEROLA, LO
通讯作者：
MEROLA, LO