Lower serum testosterone associated with elevated polychlorinated biphenyl concentrations in Native American men.
Lower serum testosterone associated with elevated polychlorinated biphenyl concentrations in Native American men.
复制标题
DOI：
10.1289/ehp.0800134
复制
发表时间：
2009-09
影响因子：
10.4
通讯作者：
Carpenter DO
中科院分区：
文献类型：
--
作者：
Goncharov A;Rej R;Negoita S;Schymura M;Santiago-Rivera A;Morse G;Akwesasne Task Force on the Environment;Carpenter DO
多氯联苯（PCBs）和氯化农药是内分泌干扰物，会改变甲状腺和雌激素激素系统。对雄激素系统的作用知之甚少。我们研究了成年印第安人（莫霍克人）血清睾酮浓度与多氯联苯和三种氯化农药水平之间的关系。我们收集了703名成年莫霍克人（257名男性和436名女性）的空腹血清样本，分析了101种多氯联苯同系物、六氯苯（HCB）、二氯二苯二氯乙烯（DDE）和米雷克斯，以及睾酮、胆固醇和甘油三酯。在控制年龄、体重指数（BMI）和其他分析因素的同时，使用逻辑回归模型评估睾酮与血清有机氯水平的分位数（包括湿重和脂质调整）之间的关系，以最低的分位数作为参考。男性和女性被分开考虑。男性睾酮浓度与总多氯联苯浓度呈负相关，无论是使用湿重还是脂质调整值。在调整年龄、BMI、总血清脂质和三种农药后，总湿重多氯联苯（最高和最低五位数）的睾酮浓度高于中位数的比值比（OR）为0.17[95%置信区间（CI）， 0.05-0.69]。调整其他分析物后，脂质调整的总PCB浓度OR为0.23 （95% CI, 0.06-0.78）。睾酮水平与多氯联苯74、99、153和206浓度呈显著负相关，而与多氯联苯52、105、118、138、170、180、201和203浓度无显著负相关。女性睾酮浓度远低于男性，且与血清多氯联苯无显著相关性。在男性和女性中，HCB、DDE和mirex与睾酮浓度无关。美洲原住民男性血清多氯联苯水平升高与血清睾酮浓度降低有关。
Polychlorinated biphenyls (PCBs) and chlorinated pesticides are endocrine disruptors, altering both thyroid and estrogen hormonal systems. Less is known of action on androgenic systems. We studied the relationship between serum concentrations of testosterone in relation to levels of PCBs and three chlorinated pesticides in an adult Native American (Mohawk) population. We collected fasting serum samples from 703 adult Mohawks (257 men and 436 women) and analyzed samples for 101 PCB congeners, hexachlorobenzene (HCB), dichlorodiphenyldichloroethylene (DDE), and mirex, as well as testosterone, cholesterol, and triglycerides. The associations between testosterone and tertiles of serum organochlorine levels (both wet weight and lipid adjusted) were assessed using a logistic regression model while controlling for age, body mass index (BMI), and other analytes, with the lowest tertile being considered the referent. Males and females were considered separately. Testosterone concentrations in males were inversely correlated with total PCB concentration, whether using wet-weight or lipid-adjusted values. The odds ratio (OR) of having a testosterone concentration above the median was 0.17 [95% confidence interval (CI), 0.05–0.69] for total wet-weight PCBs (highest vs. lowest tertile) after adjustment for age, BMI, total serum lipids, and three pesticides. The OR for lipid-adjusted total PCB concentration was 0.23 (95% CI, 0.06–0.78) after adjustment for other analytes. Testosterone levels were significantly and inversely related to concentrations of PCBs 74, 99, 153, and 206, but not PCBs 52, 105, 118, 138, 170, 180, 201, or 203. Testosterone concentrations in females are much lower than in males, and not significantly related to serum PCBs. HCB, DDE, and mirex were not associated with testosterone concentration in either men or women. Elevation in serum PCB levels is associated with a lower concentration of serum testosterone in Native American men.
登录
查看更多内容
DOI：
10.1093/gerona/56.5.m266
发表时间：
2001-05-01
影响因子：
5.1
作者：
Kenny, AM;Prestwood, KM;Raisz, LG
通讯作者：
Raisz, LG
影响因子：
10.4
作者：
Dhooge W;van Larebeke N;Koppen G;Nelen V;Schoeters G;Vlietinck R;Kaufman JM;Comhaire F;Flemish Environment and Health Study Group
通讯作者：
Flemish Environment and Health Study Group
影响因子：
--
作者：
Duan, RQ;Porter, W;Safe, S
通讯作者：
Safe, S
DOI：
10.1038/sj.jes.7500500
发表时间：
2007-05-01
影响因子：
4.5
作者：
Fitzgerald, Edward F.;Hwang, Syni-An;Tarbell, Alice
通讯作者：
Tarbell, Alice
影响因子：
4.8
作者：
Kester, MHA;Bulduk, S;Visser, TJ
通讯作者：
Visser, TJ