Heart Rate Variability: A Novel Modality for Diagnosing Neuropathic Pain after Spinal Cord Injury.
Heart Rate Variability: A Novel Modality for Diagnosing Neuropathic Pain after Spinal Cord Injury.
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DOI：
10.3389/fphys.2017.00495
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发表时间：
2017
影响因子：
4
通讯作者：
Li S
中科院分区：
文献类型：
--
作者：
Karri J;Zhang L;Li S;Chen YT;Stampas A;Li S
背景：心率变异性（HRV），即心脏R-R间期长度的生理变化，可以通过分析产生反映一个人自主神经平衡的各种参数。HRV分析可用于捕获脊髓损伤（SCI）中与慢性神经性疼痛（NP）相关的自主神经异常。本研究评估HRV参数在脊髓损伤队列中诊断NP的能力。方法：采集身体健全的受试者（AB, n = 15）、单纯SCI-NP， n = 11)和SCI+NP， n = 20的静息心电图（ECG）。采用常规时频分析方法对HRV参数进行分析。结果：静息时，各组心率无明显差异。然而，与AB组（p < 0.01）或SCI-NP组（p < 0.05）相比，由SDNN时域参数确定的SCI+NP参与者表现出较低的总体HRV。此外，AB和SCI-NP参与者在所有HRV时域和频域参数上具有统计学可比性。其他分析显示，T4组与T5组、脊髓损伤组（所有参数：p > 0.15）或C8组与T1组、脊髓损伤组（p > 0.30）之间HRV参数无差异。结论：脊髓损伤和NP患者的整体HRV较低，这可以通过HRV时域参数SDNN来确定。HRV分析是一种创新的模式，能够客观量化脊髓损伤参与者的慢性NP。
Background: Heart rate variability (HRV), the physiological variance in the heart's R-R interval length, can be analyzed to produce various parameters reflective of one's autonomic balance. HRV analysis may be used to capture those autonomic aberrations associated with chronic neuropathic pain (NP) in spinal cord injury (SCI). This study assesses the capacity of HRV parameters to diagnose NP in an SCI cohort. Methods: An electrocardiogram (ECG) was collected at rest from able bodied participants (AB, n = 15), participants with SCI only (SCI-NP, n = 11), and those with SCI and NP (SCI+NP, n = 20). HRV parameters were analyzed using conventional time and frequency analysis. Results: At rest, there were no heart rate differences amongst groups. However, SCI+NP participants demonstrated lower overall HRV, as determined by the SDNN time domain parameter, compared to either AB (p < 0.01) or SCI-NP (p < 0.05) groups. Moreover, AB and SCI-NP participants were statistically comparable for all HRV time and frequency domain parameters. Additional analyses demonstrated no differences in HRV parameters between T4, above vs. T5, below SCI groups (for all parameters: p > 0.15) or between C8, above vs. T1, below SCI groups (p > 0.30). Conclusions: Participants with SCI and NP exhibit a lower overall HRV, which can be determined by HRV time domain parameter SDNN. HRV analysis is an innovative modality with the capacity for objective quantification of chronic NP in participants with SCI.
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影响因子：
9.8
作者：
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通讯作者：
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通讯作者：
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DOI：
10.1016/j.apmr.2007.02.002
发表时间：
2007-05-01
影响因子：
4.3
作者：
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通讯作者：
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