Pancreatic cancer risk: associations with meat-derived carcinogen intake in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort.
Pancreatic cancer risk: associations with meat-derived carcinogen intake in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort.
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DOI：
10.1002/mc.20794
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发表时间：
2012-01
影响因子：
4.6
通讯作者：
Church, Timothy R.
中科院分区：
文献类型：
--
作者：
Anderson, Kristin E.;Mongin, Steven J.;Sinha, Rashmi;Stolzenberg-Solomon, Rachael;Gross, Myron D.;Ziegler, Regina G.;Mabie, Jerome E.;Risch, Adam;Kazin, Sally S.;Church, Timothy R.
流行病学研究报告了高温熟肉摄入量与胰腺癌之间的正相关。我们在一个前瞻性队列中评估了杂环胺（HCAs）和苯并（a）芘（BaP）（高温下烹饪的肉类中形成的诱变剂）的饮食摄入量与胰腺外分泌癌事件之间的关系。在前列腺、肺、结直肠和卵巢筛查试验（PLCO）中随机筛选的62，581名受试者完成了初步饮食调查，评估了肉类摄入量、烹饪方法和熟度偏好，确定了队列。直到2007年，每年都会对受试者进行癌症发病率调查。美国国家癌症研究所研究数据库（CHARRED）用于估计HCA和BaP摄入量以及调查数据中的致突变活性指数（MAI）。根据多变量考克斯回归模型，按摄入量的五分位数估计胰腺癌风险的比例风险比（HR），以最低的五分位数作为参考。在随访期间（中位数：10年），248例外分泌胰腺癌被证实。对熟透和非常熟透的肉类的偏好通常与风险增加有关。在MAI的上五分位数中发现胰腺癌风险显著升高，暴露于单个诱变剂2-氨基-3，4，8-三甲基咪唑[4，5-f]喹喔啉（DiMeIQx）和MAI的最低五分位数中，第三和第五个五分位数的HR分别为1.86（1.22，2.85）和1.87 2-氨基-3，8-二甲基咪唑[4，5-f]喹喔啉（MeIQx）。分别与（1.16，3.02）式进行比较。这三种暴露表现出显着的（P趋势：0.01-0.03）积极的风险趋势，因为它们的水平增加，消费在高温下煮熟的肉，其中含有高诱变剂水平，似乎赋予胰腺癌的风险增加。
Epidemiological studies report positive associations between high-temperature cooked meat intake and pancreatic cancer. We assessed associations between dietary intake of heterocyclic amines (HCAs) and benzo(a)pyrene (BaP)—mutagens formed in meat cooked at high temperatures—and incident exocrine pancreatic cancer in a prospective cohort. The 62,581 subjects randomized to screening in the Prostate, Lung, Colorectal and Ovarian Screening Trial (PLCO) who completed an initial dietary survey that assessed meat intake, cooking methods, and doneness preferences defined the cohort. Subjects were surveyed annually for incident cancers through 2007. A National Cancer Institute research database (CHARRED) was used to estimate HCA and BaP intake and a Mutagenic Activity Index (MAI) from survey data. Proportional hazard ratios (HRs) for risk of pancreatic cancer were estimated from multivariate Cox regression models by quintile of intake, with the lowest quintile as the referent. During follow-up (median: 10 yrs), 248 cases of exocrine pancreatic cancer were confirmed. Preferences for well and very well done meat were generally associated with increased risks. Significant elevations in pancreatic cancer risk were found in upper quintiles of MAI, and of exposure to individual mutagens 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and lowest quintile of MAI, the third and fifth quintiles brought HRs of 1.86 (1.22, 2.85) and 1.87 2-Amino-3,8-dimethylimidazo [4,5-f]quinoxaline (MeIQx). Compared to the (1.16, 3.02), respectively. These three exposures exhibited significant (P-trend: 0.01-0.03) positive trends in risk as their levels increased Consuming well-done meat cooked at high temperatures, which contains high mutagen levels, appears to confer increased risk of pancreatic cancer.
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影响因子：
3.8
作者：
Cantwell, M;Mittl, B;Sinha, R
通讯作者：
Sinha, R
影响因子：
3.8
作者：
Li, Donghui;Day, Rena Sue;Hassan, Manal M.
通讯作者：
Hassan, Manal M.
DOI：
10.1016/s0197-2456(00)00097-0
发表时间：
2000-12-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
Gohagan, JK;Prorok, PC;Kramer, BS
通讯作者：
Kramer, BS
影响因子：
3.8
作者：
Anderson, KE;Kadlubar, FF;Sinha, R
通讯作者：
Sinha, R
影响因子：
14.5
作者：
Wogan, GN;Hecht, SS;Loeb, LA
通讯作者：
Loeb, LA