Myocardial blood flow heterogeneity in shock and small-volume resuscitation in pigs with coronary stenosis.

Myocardial blood flow heterogeneity in shock and small-volume resuscitation in pigs with coronary stenosis.
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冠状动脉狭窄猪休克和小容量复苏时心肌血流异质性。

DOI:
10.1152/jappl.1997.83.6.1832
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发表时间:
1997
影响因子:
3.3
通讯作者:
K. Messmer
K. Messmer
中科院分区:
医学2区
文献类型:
--
作者:
M. Kleen;M. Welte;P. Lackermeier;O. Habler;G. Kemming;K. Messmer

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冠状动脉狭窄猪休克和小容量复苏时心肌血流异质性。j:。中国生物医学工程学报,32(6):393 - 398。我们分析了冠状动脉狭窄时休克和小容量复苏对局部心肌灌注分形维数(D)和空间相关性(SC)的影响。诱导失血性休克并维持1小时。用高渗盐水-葡聚糖60 [HSDex, 10%的出血量(SBV)]或生理盐水(NS, 80%的SBV)对猪进行复苏。用葡聚糖(10% SBV)治疗30分钟后继续治疗。基线时,D为1.39 +/- 0.06(平均+/- SE; HSDex组)和1.34 +/- 0.04 (NS组)。SC为0.26 +/- 0.07 (HSDex), 0.26 +/- 0.04 (NS)。左冠状动脉前降支狭窄既没有改变D,也没有改变SC。休克显著降低了D(即均匀灌注):1.26 +/- 0.06 (HSDex)和1.23 +/- 0.05 (NS)。SC分别增加0.41 +/- 0.1 (HSDex)和0.48 +/- 0.07 (NS)。HSDex液体疗法进一步降低D至1.22 +/- 0.05,而NS无变化,SC升高HSDex(0.56 +/- 0.1)和NS(0.53 +/- 0.06)。复苏后1 h,两组SC不变,仅NS组D降低(1.18 +/- 0.02)。我们的结论是,失血性休克使冠状动脉狭窄的局部心肌灌注均匀化,而液体治疗未能恢复这种情况。
Myocardial blood flow heterogeneity in shock and small-volume resuscitation in pigs with coronary stenosis. J. Appl. Physiol. 83(6): 1832-1841, 1997.-We analyzed the effects of shock and small-volume resuscitation in the presence of coronary stenosis on fractal dimension (D) and spatial correlation (SC) of regional myocardial perfusion. Hemorrhagic shock was induced and maintained for 1 h. Pigs were resuscitated with hypertonic saline-dextran 60 [HSDex, 10% of shed blood volume (SBV)] or normal saline (NS; 80% of SBV). Therapy was continued after 30 min with dextran (10% SBV). At baseline, D was 1.39 +/- 0.06 (mean +/- SE; HSDex group) and 1.34 +/- 0.04 (NS group). SC was 0.26 +/- 0.07 (HSDex) and 0.26 +/- 0.04 (NS). Left anterior descending coronary artery stenosis changed neither D nor SC. Shock significantly reduced D (i.e., homogenized perfusion): 1.26 +/- 0.06 (HSDex) and 1.23 +/- 0.05 (NS). SC was increased: 0.41 +/- 0.1 (HSDex) and 0.48 +/- 0.07 (NS). Fluid therapy with HSDex further decreased D to 1.22 +/- 0.05, whereas NS did not change D. SC was increased by both HSDex (0.56 +/- 0.1) and NS (0.53 +/- 0.06). At 1 h after resuscitation, SC was constant in both groups, and D was reduced only in the NS group (1.18 +/- 0.02). We conclude that hemorrhagic shock homogenized regional myocardial perfusion in coronary stenosis and that fluid therapy failed to restore this.
失血性休克中的毛细血管狭窄可通过高渗盐水-右旋糖酐回输来纠正。
DOI: --
发表时间: 1990
期刊: Circulatory shock
影响因子: --
作者:
Mazzoni,MC;Borgström,P;Intaglietta,M;Arfors,KE
通讯作者: Arfors,KE
DOI: 10.1161/01.cir.95.2.522
发表时间: 1997
期刊: Circulation
影响因子: 37.8
作者:
Chilian,WM
通讯作者: Chilian,WM
心脏%20收缩性%20和%20血液%20流量%20分布%20以下%20复苏%20和%207.5%%20高渗%20盐水%20in%20麻醉%20狗。
DOI: --
发表时间: 1991
期刊: Circulatory shock
影响因子: --
作者:
Kien,ND;Reitan,JA;White,DA;Wu,CH;Eisele,JH
通讯作者: Eisele,JH