Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8(+) TCR-Vβ(+) expansions.
Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8(+) TCR-Vβ(+) expansions.
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DOI：
10.1038/s41598-017-18062-x
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发表时间：
2018-02-07
影响因子：
4.6
通讯作者：
Wooldridge L
中科院分区：
文献类型：
--
作者：
Lissina A;McLaren JE;Ilander M;Andersson EI;Lewis CS;Clement M;Herman A;Ladell K;Llewellyn-Lacey S;Miners KL;Gostick E;Melenhorst JJ;Barrett AJ;Price DA;Mustjoki S;Wooldridge L
CD8+ T-cell expansions are the primary manifestation of T-cell large granular lymphocytic leukemia (T-LGLL), which is frequently accompanied by neutropenia and rheumatoid arthritis, and also occur as a secondary phenomenon in leukemia patients treated with dasatinib, notably in association with various drug-induced side-effects. However, the mechanisms that underlie the genesis and maintenance of expanded CD8+ T-cell receptor (TCR)-Vβ+ populations in these patient groups have yet to be fully defined. In this study, we performed a comprehensive phenotypic and clonotypic assessment of expanded (TCR-Vβ+) and residual (TCR-Vβ−) CD8+ T-cell populations in T-LGLL and dasatinib-treated chronic myelogenous leukemia (CML) patients. The dominant CD8+ TCR-Vβ+ expansions in T-LGLL patients were largely monoclonal and highly differentiated, whereas the dominant CD8+ TCR-Vβ+ expansions in dasatinib-treated CML patients were oligoclonal or polyclonal, and displayed a broad range of memory phenotypes. These contrasting features suggest divergent roles for antigenic drive in the immunopathogenesis of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions.
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影响因子：
15.9
作者：
Epling-Burnette, PK;Liu, JH;Loughran, TP
通讯作者：
Loughran, TP
DOI：
10.3324/haematol.2009.018481
发表时间：
2010-09-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Bareau, Benoit;Rey, Jerome;Lamy, Thierry
通讯作者：
Lamy, Thierry
DOI：
10.1038/sj.thj.6200212
发表时间：
2003-01-01
期刊：
The hematology journal : the official journal of the European Haematology Association
影响因子：
--
作者：
Melenhorst, J Joseph;Eniafe, Rhoda;Barrett, A John
通讯作者：
Barrett, A John
影响因子：
56.9
作者：
Altman, JD;Moss, PAH;Davis, MM
通讯作者：
Davis, MM
DOI：
10.4049/jimmunol.0900182
发表时间：
2009-07-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Petrovas C;Chaon B;Ambrozak DR;Price DA;Melenhorst JJ;Hill BJ;Geldmacher C;Casazza JP;Chattopadhyay PK;Roederer M;Douek DC;Mueller YM;Jacobson JM;Kulkarni V;Felber BK;Pavlakis GN;Katsikis PD;Koup RA
通讯作者：
Koup RA