Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications.
Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications.
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DOI：
10.1039/c4cc00968a
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发表时间：
2014-10-14
期刊：
影响因子：
--
通讯作者：
Xian M
中科院分区：
文献类型：
--
作者：
Zhao Y;Biggs TD;Xian M
硫化氢（H2S）是一种新发现的具有细胞保护作用的信号分子。近年来，H2S生理学和药理学领域迅速发展，但必须解决一些基本问题，以促进我们对未来H2S生物学和临床潜力的理解。硫化氢释放剂（也称为H2S供体）已广泛用于该领域。这些化合物不仅是有用的研究工具，而且是潜在的治疗剂。因此，重要的是研究外源性H2S的化学和药理学，并了解与用于在体外和体内产生H2S的供体的选择相关的限制。本文综述了H2S气体、硫盐、大蒜硫化合物、Lawesson试剂/类似物、1，2-二硫杂环戊烯-3-硫酮、巯基活化供体、光笼化供体和硫代氨基酸等几种常用供体的研究进展和局限性。本文还讨论了这些供体的生物学应用。
Hydrogen sulfide (H2S) is a newly recognized signaling molecule with very potent cytoprotective actions. The fields of H2S physiology and pharmacology have been rapidly growing in recent years, but a number of fundamental issues must be addressed to advance our understanding of the biology and clinical potential of H2S in the future. Hydrogen sulfide releasing agents (also known as H2S donors) have been widely used in the field. These compounds are not only useful research tools, but also potential therapeutic agents. It is therefore important to study the chemistry and pharmacology of exogenous H2S and to be aware of the limitations associated with the choice of donors used to generate H2S in vitro and in vivo. In this review we summarized the developments and limitations of current available donors including H2S gas, sulfide salts, garlic-derived sulfur compounds, Lawesson’s reagent/analogs, 1,2-dithiole-3-thiones, thiol-activated donors, photo-caged donors, and thioamino acids. Some biological applications of these donors were also discussed.
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影响因子：
20.1
作者：
Calvert JW;Jha S;Gundewar S;Elrod JW;Ramachandran A;Pattillo CB;Kevil CG;Lefer DJ
通讯作者：
Lefer DJ
影响因子：
37.8
作者：
Calvert JW;Elston M;Nicholson CK;Gundewar S;Jha S;Elrod JW;Ramachandran A;Lefer DJ
通讯作者：
Lefer DJ
影响因子：
56.9
作者：
DAWSON, PE;MUIR, TW;KENT, SBH
通讯作者：
KENT, SBH
影响因子：
4.2
作者：
Amagase, H
通讯作者：
Amagase, H
影响因子：
56.9
作者：
Blackstone, E;Morrison, M;Roth, MB
通讯作者：
Roth, MB