Reducing the effect of non-stationary resolution on activity quantitation with the frequency distance relationship in SPECT
Reducing the effect of non-stationary resolution on activity quantitation with the frequency distance relationship in SPECT
复制标题
利用 SPECT 中的频率距离关系减少非平稳分辨率对活性定量的影响
DOI：
10.1109/nssmic.1995.510497
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
D. Luo
中科院分区：
文献类型：
--
作者：
P. H. Pretorius;Matt A. King;S. Glick;Tin;D. Luo
定量参数（例如体积中的最大计数和总计数）的确定受到部分体积效应的影响。这种效应的大小随 SPECT 成像中固有的非平稳空间分辨率（与物体的大小和形状相比）以及物体相对于其背景的相对浓度的变化而变化。本研究的目的是确定 FDR（频率距离关系）恢复过滤是否可以减少距离相关的空间分辨率对活动定量的影响。使用结合了衰减和距离相关模糊的分析投影仪来模拟圆柱形衰减器中的小型热球形物体，如 LEUHR 准直器所成像。使用贝里尼方法进行衰减校正后，采用不同高斯和参数维纳滤波器进行正则化的 FDR 恢复滤波。还使用 Bellini 的衰减校正方法处理投影，然后使用不同截止频率的滤波反投影和 3D 巴特沃斯滤波。 CCR（中心计数比）和 TCR（总计数比）被确定为观察到的计数与真实计数的比值。结果表明，FDR 恢复后，CCR 和 TCR 变得大致位置不变。然而，当使用高斯函数对 FDR 逆滤波器进行正则化时，随着标准差 (/spl sigma/) 降低到旋转中心的标准差以下，CCR 变得高度不稳定。使用高斯和参数维纳滤波器来规范 FDR 滤波会在 CCR 中引入噪声，但会提高 TCR 相对于旋转中心的恢复。
The determination of quantitative parameters such as the maximum and total counts in a volume are influenced by the partial volume effect. The magnitude of this effect varies with the non-stationary spatial resolution inherent in SPECT imaging compared to the size and shape of the object, and the relative concentration of the object to its background. The objective of this investigation was to determine if the FDR (Frequency Distance Relationship) restoration filtering can reduce the impact of distance dependent spatial resolution on the quantitation of activity. An analytical projector which incorporates attenuation and distance dependent blurring was used to simulate small hot spherical objects in an cylindrical attenuator as imaged with a LEUHR collimator. FDR restoration filtering regularized using different Gaussian and parametric Wiener filters, was employed after attenuation correction with Bellini's method. Projections were also processed using Bellini's attenuation correction method followed by filtered backprojection and 3D Butterworth filtering with different cut-off frequencies. CCR's (Center Count Ratios) and TCR's (Total Count Ratios) were determined as the observed counts over true counts. Results show that after FDR restoration the CCR and TCR become approximately position invariant. However, when regularizing the FDR inverse filter with a Gaussian function, CCR's become highly unstable as the standard deviation (/spl sigma/) decreased below that at the center of rotation. The use of the Gaussian and parametric Wiener filters to regularize FDR filtering introduce noise in the CCR's but improve recovery of TCR's over that of the center of rotation.
猴子 SPECT CNS 多巴胺受体研究的浓度回收。
影响因子：
3.8
作者：
Shao,L;Billings,J;Pfeiffer,N;Kung,HF
通讯作者：
Kung,HF
一种用于散射校正的双光峰窗方法。
DOI：
--
发表时间：
1992
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
King,MA;Hademenos,GJ;Glick,SJ
通讯作者：
Glick,SJ
使用散射光子补偿改进 SPECT 量化。
DOI：
--
发表时间：
1984
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Jaszczak,RJ;Greer,KL;FloydJr,CE;Harris,CC;Coleman,RE
通讯作者：
Coleman,RE