Anti-inflammatory effect of myristicin on RAW 264.7 macrophages stimulated with polyinosinic-polycytidylic acid.
Anti-inflammatory effect of myristicin on RAW 264.7 macrophages stimulated with polyinosinic-polycytidylic acid.
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DOI：
10.3390/molecules16087132
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Park W
中科院分区：
文献类型：
--
作者：
Lee JY;Park W
肉豆蔻素(1-烯丙基-5-甲氧基-3，4-亚甲二氧基苯)是一种活性芳香化合物，存在于肉豆蔻、胡萝卜、罗勒、肉桂和欧芹中。肉豆蔻素已被认为具有抗胆碱能、抗菌和保肝作用，然而，肉豆蔻素对病毒刺激的巨噬细胞的作用尚未完全报道。本研究观察了肉豆蔻素对双链RNA(DsRNA)刺激的巨噬细胞的抗炎作用。肉豆蔻素在50µM浓度下对RAW 264.7小鼠巨噬细胞的细胞活力无明显影响。肉豆蔻素显著抑制多聚肌胞苷多聚胞苷诱导的RAW 264.7细胞产生钙离子、一氧化氮、白介素6、白介素10、干扰素诱导蛋白10、单核细胞趋化蛋白1、单核细胞趋化蛋白3、粒细胞巨噬细胞集落刺激因子、巨噬细胞炎性蛋白1α、巨噬细胞炎性蛋白1β和白血病抑制因子。综上所述，肉豆蔻素的抗炎作用与其通过钙途径抑制dsRNA刺激的巨噬细胞中的NO、细胞因子、趋化因子和生长因子有关。
Myristicin (1-allyl-5-methoxy-3,4-methylenedioxybenzene) is an active aromatic compound found in nutmeg (the seed of Myristica fragrans), carrot, basil, cinnamon, and parsley. Myristicin has been known to have anti-cholinergic, antibacterial, and hepatoprotective effects, however, the effects of myristicin on virus-stimulated macrophages are not fully reported. In this study, the anti-inflammatory effect of myristicin on double-stranded RNA (dsRNA)-stimulated macrophages was examined. Myristicin did not reduce the cell viability of RAW 264.7 mouse macrophages at concentrations of up to 50 µM. Myristicin significantly inhibited the production of calcium, nitric oxide (NO), interleukin (IL)-6, IL-10, interferon inducible protein-10, monocyte chemotactic protein (MCP)-1, MCP-3, granulocyte-macrophage colony-stimulating factor, macrophage inflammatory protein (MIP)-1α, MIP-1β, and leukemia inhibitory factor in dsRNA [polyinosinic-polycytidylic acid]-induced RAW 264.7 cells (P < 0.05). In conclusion, myristicin has anti-inflammatory properties related with its inhibition of NO, cytokines, chemokines, and growth factors in dsRNA-stimulated macrophages via the calcium pathway.
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影响因子：
4.8
作者：
Pereira, Renata M. S.;Dias Teixeira, Karina Luiza;Lopes, Ulisses G.
通讯作者：
Lopes, Ulisses G.
影响因子：
4.4
作者：
White, Kimberly E.;Ding, Qiang;Olman, Mitchell A.
通讯作者：
Olman, Mitchell A.
DOI：
10.1006/bbrc.1997.7053
发表时间：
1997-07-30
影响因子：
3.1
作者：
Ahmad, H;Tijerina, MT;Tobola, AS
通讯作者：
Tobola, AS
DOI：
10.2174/1568010033484296
发表时间：
2003-06-01
期刊：
Current Drug Targets - Inflammation and Allergy
影响因子：
--
作者：
Ito, Hiroaki
通讯作者：
Ito, Hiroaki
影响因子：
4.4
作者：
Stout, Barbara A.;Melendez, Karla;Tesfaigzi, Yohannes
通讯作者：
Tesfaigzi, Yohannes