Shared genetic vulnerability for disordered gambling and alcohol use disorder in men and women: evidence from a national community-based Australian Twin Study.
Shared genetic vulnerability for disordered gambling and alcohol use disorder in men and women: evidence from a national community-based Australian Twin Study.
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男女共享遗传脆弱性赌博和饮酒障碍：来自国家社区的澳大利亚双胞胎研究的证据。
DOI：
10.1017/thg.2013.11
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发表时间：
2013-04
影响因子：
0.9
通讯作者：
Martin, Nicholas G.
中科院分区：
文献类型：
--
作者：
Slutske, Wendy S.;Ellingson, Jarrod M.;Richmond-Rakerd, Leah S.;Zhu, Gu;Martin, Nicholas G.
赌博障碍（DG）将很快与物质使用障碍沿着被纳入精神障碍诊断和统计手册DSM-5的修订诊断类别，称为“物质使用和成瘾性障碍”。这在一定程度上是基于DG和物质使用障碍的常见病因。使用来自全国社区的澳大利亚双胞胎登记处的数据，我们使用生物计量模型拟合来检查DG和酒精使用障碍（AUD）的遗传责任共享的程度，以及男性和女性是否存在差异。探讨了使用分类与维度DG和AUD表型的效果，以及使用基于DSM-IV和拟议的DSM-5诊断标准的诊断的效果。DG与AUD的遗传相关系数为0.29 ~ 0.44。当使用维度表型时，男性DG和AUD之间的遗传相关性显著大于女性。总的来说，DG和AUD之间约有二分之一到三分之二的关联是由于共同的遗传脆弱性。这项研究是为数不多的经验性证据之一，表明DG和另一种物质相关成瘾性疾病的遗传风险存在重叠。需要更多的研究DG和其他物质使用障碍之间的遗传重叠，以及DG和其他（非物质相关的）精神疾病之间的遗传重叠。
Disordered gambling (DG) will soon be included along with the substance use disorders in a revised diagnostic category of the Diagnostic and Statistical Manual of Mental Disorders DSM-5 called ‘Substance Use and Addictive Disorders’. This was premised in part on the common etiologies of DG and the substance use disorders. Using data from the national community-based Australian Twin Registry, we used biometric model fitting to examine the extent to which the genetic liabilities for DG and alcohol use disorder (AUD) were shared, and whether this differed for men and women. The effect of using categorical versus dimensional DG and AUD phenotypes was explored, as was the effect of using diagnoses based on the DSM-IV and the proposed DSM-5 diagnostic criteria. The genetic correlations between DG and AUD ranged from 0.29 to 0.44. There was a significantly larger genetic correlation between DG and AUD among men than women when using dimensional phenotypes. Overall, about one-half to two-thirds of the association between DG and AUD was due to a shared genetic vulnerability. This study represents one of the few empirical demonstrations of an overlap in the genetic risk for DG and another substance-related addictive disorder. More research is needed on the genetic overlap between DG and other substance use disorders, as well as the genetic overlap between DG and other (non-substance-related) psychiatric disorders.
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影响因子：
4.4
作者：
LaPlante, Debi A.;Nelson, Sarah E.;Shaffer, Howard J.
通讯作者：
Shaffer, Howard J.
DOI：
10.3109/00952990.2010.491884
发表时间：
2010-09
期刊：
The American journal of drug and alcohol abuse
影响因子：
--
作者：
Grant JE;Potenza MN;Weinstein A;Gorelick DA
通讯作者：
Gorelick DA
DOI：
10.1093/cercor/bhn172
发表时间：
2009-06
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Lee TM;Chan CC;Leung AW;Fox PT;Gao JH
通讯作者：
Gao JH
影响因子：
2.4
作者：
Ellery, Michael;Stewart, Sherry H.;Loba, Pamela
通讯作者：
Loba, Pamela
全国合并症调查复制中的DSM-IV病理赌博。
影响因子：
6.9
作者：
Kessler, R. C.;Hwang, I.;LaBrie, R.;Petukhova, M.;Sampson, N. A.;Winters, K. C.;Shaffer, H. J.
通讯作者：
Shaffer, H. J.