Sex-related differences in neural activity during risk taking: an fMRI study.
Sex-related differences in neural activity during risk taking: an fMRI study.
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DOI：
10.1093/cercor/bhn172
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Gao JH
中科院分区：
文献类型：
--
作者：
Lee TM;Chan CC;Leung AW;Fox PT;Gao JH
本研究探讨了性别对冒险过程的影响。我们观察到，女性参与者（n = 10）在执行风险收益任务时，右侧和双侧眶额皮质（OFC）的激活比男性参与者（n = 12）更强。女性受试者在接受惩罚反馈后，中央前区、中央后区和中央旁区也表现出更强的激活。此外，女性参与者的大脑皮层神经活动强度与危险行为的发生率相关，但男性参与者则不然。同样，右侧眶额皮层的信号变化百分比与女性群体选择风险选择的比率呈负相关。这些研究结果强烈表明，在冒险任务中，性别对大脑活动的调节有影响。当承担相同水平的风险时，相对于男性，女性倾向于参与更多的神经处理，涉及小脑和眶额皮层，以更新和评估与冒险决策相关的可能的不确定性。这些结果与基于价值的决策模型是一致的，并提供了深入了解潜在的不同的风险承担态度的男性和女性的神经机制。
This study explored sex effects on the process of risk-taking. We observed that the female participants (n = 10) showed stronger activation in the right insula and bilateral orbitofrontal cortex (OFC) than did the male participants (n = 12) while they were performing in the Risky-Gains task. The female participants also showed stronger activations in the precentral, postcentral, and paracentral regions after receiving punishment feedback. In addition, the strength of neural activity in the insula correlated with the rate of risky behaviors for the female participants but not for the male participants. Similarly, the percent signal changes in the right OFC correlated negatively with the rate of selecting risky choices for the female group. These findings strongly suggest a sex-related influence modulating brain activity during risk-taking tasks. When taking the same level of risk, relative to men, women tend to engage in more neural processing involving the insula and the OFC to update and valuate possible uncertainty associated with risk-taking decision making. These results are consistent with the value-based decision-making model and offer insights into the possible neural mechanisms underlying the different risk-taking attitudes of men and women.
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