LOX-1 and angiotensin receptors, and their interplay.
LOX-1 and angiotensin receptors, and their interplay.
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DOI：
10.1007/s10557-011-6331-7
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发表时间：
2011-10
影响因子：
3.4
通讯作者：
Mehta JL
中科院分区：
文献类型：
--
作者：
Wang X;Phillips MI;Mehta JL
肾素-血管紧张素系统（RAS）在调节血压、水盐平衡及心血管疾病的发病中起着重要作用。血管紧张素II（Angiotensin II，Ang II）是RAS的重要生理活性介质，参与RAS的主要病理生理过程。Ang II通过激活其受体发挥作用，主要是1型（AT 1 R）和2型（AT 2 R）。大多数已知的血管紧张素II的病理生理作用是由AT 1 R激活介导的。AT 2 R的确切生理功能尚不清楚。一般认为，AT 2 R对抗AT 1 R的作用。凝集素样氧化低密度脂蛋白清道夫受体-1（LOX-1）是负责结合、内化和降解ox-LDL的主要受体之一。已知LOX-1的活化与许多病理生理学事件相关，包括内皮功能障碍和损伤、成纤维细胞生长和血管平滑肌细胞肥大。这些改变中的许多存在于动脉粥样硬化、高血压、心肌缺血和重构中。越来越多的证据表明LOX-1和Ang II受体之间存在相互作用。它们的相互作用体现在它们的表达和活动的相互调节中。它们的相互作用涉及一系列信号。最近的研究表明，活性氧（ROS），一氧化氮（NO），蛋白激酶C（PKC）和丝裂原活化蛋白激酶（MAPK）是负责它们的串扰的重要信号。本文就血脂异常与RAS激活的关系作一综述。
The renin-angiotensin system (RAS) plays an important role in regulating blood pressure, water-salt balance and the pathogenesis of cardiovascular diseases. Angiotensin II (Ang II) is the physiologically active mediator and mediates the main pathophysiological actions in RAS. Ang II exerts the effects by activating its receptors, primarily type 1 (AT1R) and type 2 (AT2R). Most of the known pathophysiological effects of Ang II are mediated by AT1R activation. The precise physiological function of AT2R is still not clear. Generally, AT2R is considered to oppose the effects of AT1R. Lectin-like oxidized low-density lipoprotein scavenger receptor-1 (LOX-1) is one of the major receptors responsible for binding, internalizing and degrading ox-LDL. The activation of LOX-1 has been known to be related to many pathophysiological events, including endothelial dysfunction and injury, fibroblast growth, and vascular smooth muscle cell hypertrophy. Many of these alterations are present in atherosclerosis, hypertension, and myocardial ischemia and remodeling. A growing body of evidence suggests the existence of a cross-talk between LOX-1 and Ang II receptors. Their interplays are embodied in the reciprocal regulation of their expression and activity. Their interplays are involved in a series of signals. Recent studies suggests that reactive oxygen species (ROS), nitric oxide (NO), protein kinase C (PKC) and mitogen activated protein kinases (MAPKs) are important signals responsible for their cross-talk. This paper reviews these aspects of dyslipidemia and RAS activation.
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影响因子：
13.5
作者：
Cuadra AE;Shan Z;Sumners C;Raizada MK
通讯作者：
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影响因子：
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作者：
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作者：
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通讯作者：
Mehta, JL
DOI：
10.1161/01.atv.0000209998.73303.b5
发表时间：
2006-05-01
影响因子：
8.7
作者：
Chen, JW;Liu, Y;Mehta, JL
通讯作者：
Mehta, JL