Histidine decarboxylase expression and histamine metabolism in gastric oxyntic mucosa during hypergastrinemia and carcinoid tumor formation.
Histidine decarboxylase expression and histamine metabolism in gastric oxyntic mucosa during hypergastrinemia and carcinoid tumor formation.
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高胃泌素血症和类癌瘤形成过程中胃泌酸粘膜中组氨酸脱羧酶的表达和组胺代谢。
DOI：
10.1210/endo.137.10.8828505
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发表时间：
1996
期刊：
影响因子：
4.8
通讯作者：
O. Nilsson
中科院分区：
文献类型：
--
作者：
L. Kölby;B. Wängberg;H. Ahlman;I. Modlin;G. Granerus;E. Theodorsson;O. Nilsson
组胺是胃酸分泌的重要刺激物。在实验动物中，通过长期阻断组胺2受体抑制胃酸分泌导致高胃泌素血症、肠嗜铬样（ECL）细胞增殖和产生组胺的胃类癌形成。本研究的目的是探讨胃泌素在正常，增生和癌样乳腺鼠natalensis泌酸粘膜组胺合成和代谢的作用。外源性胃泌素给药正常动物增加组氨酸脱羧酶（HDC）信使RNA（mRNA）的表达在30分钟内的泌酸粘膜，表明胃泌素刺激组胺合成通过调节HDC mRNA丰度。内源性高胃泌素血症，短期组胺2受体阻断剂（洛昔替丁）诱导3-29天，不诱导肿瘤，但增加HDC mRNA的表达（2- 4倍升高）和组胺含量（2倍升高）在泌酸粘膜。长期组胺2受体阻断（7-21个月）导致持续高胃泌素血症和ECL肿瘤形成。荷瘤动物的泌酸粘膜的HDC mRNA表达和组胺含量增加了4倍。组胺代谢产物甲基咪唑乙酸的尿排泄量增加2倍。从组胺2受体阻滞剂中恢复的荷瘤动物是正常的胃泌素血症，并且在泌酸粘膜中具有正常水平的HDC mRNA和组胺，以及正常的甲基咪唑乙酸排泄。结果表明，ECL细胞类癌在高胃泌素血症发展是分化良好的肿瘤，响应高胃泌素水平与组胺合成和分泌增加。
Histamine is an important stimulator of gastric acid secretion. In experimental animals, inhibition of acid secretion by long term histamine2 receptor blockade causes hypergastrinemia, proliferation of enterochromaffin-like (ECL) cells, and formation of histamine-producing gastric carcinoids. The aim of this study was to examine the role of gastrin in histamine synthesis and metabolism of the oxyntic mucosa of normal, hyperplastic, and carcinoid-bearing Mastomys natalensis. Administration of exogenous gastrin to normal animals increased histidine decarboxylase (HDC) messenger RNA (mRNA) expression in the oxyntic mucosa within 30 min, indicating that gastrin stimulates histamine synthesis by regulating HDC mRNA abundance. Endogenous hypergastrinemia, induced by short term histamine2 receptor blockade (loxtidine) for 3-29 days, did not induce tumors, but enhanced the expression of HDC mRNA (2- to 4-fold elevated) and histamine contents (2-fold elevated) in the oxyntic mucosa. Long term histamine2 receptor blockade (7-21 months) resulted in sustained hypergastrinemia and ECL tumor formation. Tumor-bearing animals had a 4-fold increase in HDC mRNA expression and histamine contents of the oxyntic mucosa. Urinary excretion of the histamine metabolite methyl-imidazole-acetic acid was 2-fold elevated. Tumor-bearing animals recovering from histamine2 receptor blockade were normogastrinemic and had normal levels of HDC mRNA and histamine in the oxyntic mucosa as well as normal excretion of methyl-imidazole-acetic acid. The results indicate that ECL cell carcinoids developing during hypergastrinemia are well differentiated tumors that respond to high gastrin levels with increased histamine synthesis and secretion.
大鼠肠嗜铬样细胞分泌组胺。
影响因子：
29.4
作者：
Prinz,C;Kajimura,M;Scott,DR;Mercier,F;Helander,HF;Sachs,G
通讯作者：
Sachs,G
大鼠肠嗜铬样细胞上的生长抑素受体亚型。
影响因子：
29.4
作者：
Prinz,C;Sachs,G;Walsh,JH;Coy,DH;Wu,SV
通讯作者：
Wu,SV
胃泌素对原代培养中分离的大鼠肠嗜铬样细胞的影响。
DOI：
10.1152/ajpgi.1994.267.4.g663
发表时间：
1994
期刊：
The American journal of physiology
影响因子：
--
作者：
Prinz,C;Scott,DR;Hurwitz,D;Helander,HF;Sachs,G
通讯作者：
Sachs,G