Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus.
Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus.
复制标题
DOI：
10.1016/j.celrep.2022.111341
复制
发表时间：
2022-09-13
期刊：
影响因子：
8.8
通讯作者：
Golovkina, Tatyana
中科院分区：
文献类型：
--
作者：
Spring, Jessica;Khan, Aly A.;Lara, Sophie;O'Grady, Kelly;Wilks, Jessica;Gurbuxani, Sandeep;Erickson, Steven;Fischbach, Michael;Jacobson, Amy;Chervonsky, Alexander;Golovkina, Tatyana
微生物群对病毒传播和复制的影响已得到充分认识。然而，它在传播/复制控制之外对逆转录病毒发病机制的影响尚不清楚。利用小鼠白血病病毒（MuLV），我们发现一些共生菌促进了这种逆转录病毒诱导的白血病的发展。共生体促进白血病的发展是由于通过上调几种免疫负调节因子来抑制适应性免疫反应。这些负调节因子包括Serpinb9b和Rnf128，它们与一些自发性人类癌症的不良预后相关。Serpinb9b的上调是通过NOD1/NOD2/RIPK2途径感知细菌介导的。这项工作描述了微生物群促进远端内脏器官肿瘤发生的机制，并指出了癌症治疗的潜在靶点。Spring等研究表明，共生菌通过抑制适应性免疫反应促进病毒诱导白血病的发展。抑制是由负性免疫调节因子的上调和肿瘤发生的驱动因子Rnf128和Serpinb9b介导的。
The influence of the microbiota on viral transmission and replication is well appreciated. However, its impact on retroviral pathogenesis outside of transmission/replication control remains unknown. Using murine leukemia virus (MuLV), we found that some commensal bacteria promoted the development of leukemia induced by this retrovirus. The promotion of leukemia development by commensals is due to suppression of the adaptive immune response through upregulation of several negative regulators of immunity. These negative regulators include Serpinb9b and Rnf128, which are associated with a poor prognosis of some spontaneous human cancers. Upregulation of Serpinb9b is mediated by sensing of bacteria by the NOD1/NOD2/RIPK2 pathway. This work describes a mechanism by which the microbiota enhances tumorigenesis within gut-distant organs and points at potential targets for cancer therapy. Spring et al. show that commensal bacteria promote the development of virally induced leukemia through suppression of the adaptive immune response. Suppression is mediated by the upregulation of negative immune regulators and by drivers of tumorigenesis, Rnf128 and Serpinb9b.
登录
查看更多内容
gnotobiotic小鼠模型表明，饮食纤维以微生物群和丁酸酯依赖性方式预防结肠直肠肿瘤发生。
影响因子：
28.2
作者：
Donohoe DR;Holley D;Collins LB;Montgomery SA;Whitmore AC;Hillhouse A;Curry KP;Renner SW;Greenwalt A;Ryan EP;Godfrey V;Heise MT;Threadgill DS;Han A;Swenberg JA;Threadgill DW;Bultman SJ
通讯作者：
Bultman SJ
影响因子：
6
作者：
Cuffaro B;Assohoun ALW;Boutillier D;Súkeníková L;Desramaut J;Boudebbouze S;Salomé-Desnoulez S;Hrdý J;Waligora-Dupriet AJ;Maguin E;Grangette C
通讯作者：
Grangette C
DOI：
10.1126/science.1224820
发表时间：
2012-10-05
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arthur JC;Perez-Chanona E;Mühlbauer M;Tomkovich S;Uronis JM;Fan TJ;Campbell BJ;Abujamel T;Dogan B;Rogers AB;Rhodes JM;Stintzi A;Simpson KW;Hansen JJ;Keku TO;Fodor AA;Jobin C
通讯作者：
Jobin C
影响因子：
46.9
作者：
Bray, Nicolas L.;Pimentel, Harold;Pachter, Lior
通讯作者：
Pachter, Lior
影响因子：
4.8
作者：
Hasegawa, Mizuho;Yang, Kangkang;Inohara, Naohiro
通讯作者：
Inohara, Naohiro