Design strategies for physical-stimuli-responsive programmable nanotherapeutics.
Design strategies for physical-stimuli-responsive programmable nanotherapeutics.
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DOI:
10.1016/j.drudis.2018.04.003
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发表时间:
2018-05
影响因子:
7.4
通讯作者:
Lowe TL
中科院分区:
文献类型:
--
作者:
Sahle FF;Gulfam M;Lowe TL
Nanomaterials that respond to externally applied physical stimuli such as temperature, light, ultrasound, magnetic field and electric field have shown great potential for controlled and targeted delivery of therapeutic agents. However, the body of literature on programming these stimuli-responsive nanomaterials to attain the desired level of pharmacologic responses is still fragmented and has not been systematically reviewed. The purpose of this review is to summarize and synthesize the literature on various design strategies for simple and sophisticated programmable physical stimuli-responsive nanotherapeutics.
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