Detection of Early Glaucomatous Damage: Performance of Summary Statistics From Optical Coherence Tomography and Perimetry.
Detection of Early Glaucomatous Damage: Performance of Summary Statistics From Optical Coherence Tomography and Perimetry.
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DOI：
10.1167/tvst.11.3.36
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发表时间：
2022-03-02
影响因子：
3
通讯作者：
Hood D
中科院分区：
文献类型：
--
作者：
Tsamis E;La Bruna S;Leshno A;De Moraes CG;Hood D
评估 OCT 和 VF 报告中提供的光学相干断层扫描 (OCT) 和视野 (VF) 摘要统计数据（指标）的诊断性能。从 56 只健康对照 (HC) 眼睛/参与者和 61 只眼睛/患者获得 OCT 视盘和黄斑扫描以及 24-2 和 10-2 VF，24-2 平均偏差优于 –6 dB。所有指标均通过 OCT 径向、圆形和后极立方体扫描以及 24-2 和 10-2 VF 获得。他们的诊断表现被单独和组合地评估。为了特异性，使用了 56 只 HC 眼睛。就敏感性而言，根据评估结构-功能 (S-F) 一致性的自动地形图方法，61 名患者眼睛中的 40 只被认为可能患有青光眼。这 40 只眼睛中的任何一只根据任何给定指标均未判定为异常，则被视为假阴性。所有单一 OCT 和 VF 指标均将 HC 错误分类为青光眼，并错过了可能患有青光眼的眼睛。表现最好的单一指标是 3.5 毫米圆形扫描的颞下厚度，具有 96% 的特异性和 83% 的敏感性。 OCT-OCT 和 OCT-VF 指标的组合显着提高了特异性。新提出的评估半场水平结构-结构（S-S）一致性的指标具有最高的准确性。该 S-S 指标的特异性为 98%，敏感性为 80%。 OCT 和 VF 指标，无论是单独使用还是组合使用，对于患有早期青光眼的眼睛仅具有中等敏感性。评估 S-S 或 S-F 一致性的 OCT 和 VF 指标组合可以具有高度特异性，这对于临床和研究目的具有重要意义。
To evaluate the diagnostic performance of optical coherence tomography (OCT) and visual field (VF) summary statistics (metrics) that are available in OCT and VF reports. OCT disc and macular scans and 24-2 and 10-2 VFs were obtained from 56 healthy control (HC) eyes/participants and 61 eyes/patients with 24-2 mean deviation of better than –6 dB. All metrics were obtained from OCT radial, circle, and posterior pole cube scans and 24-2 and 10-2 VFs. Their diagnostic performances were evaluated, in isolation and in combinations. For specificity, the 56 HC eyes were used. For sensitivity, 40 of the 61 patient eyes were deemed likely glaucomatous based on an automated topographic method that evaluates structure–function (S–F) agreement. Any 1 of these 40 eyes not judged as abnormal by any given metric was considered a false negative. All single OCT and VF metrics misclassified HCs as glaucomatous and missed likely glaucomatous eyes. The best performing single metric was the temporal inferior thickness of the 3.5-mm circle scan, with 96% specificity and 83% sensitivity. Combinations of OCT–OCT and OCT–VF metrics markedly improved specificity. A newly proposed metric that evaluates structure–structure (S–S) agreement at a hemifield level had the highest accuracy. This S–S metric had 98% specificity and 80% sensitivity. OCT and VF metrics, single or in combinations, have only moderate sensitivity for eyes with early glaucoma. OCT and VF metrics combinations evaluating S–S or S–F agreement can be highly specific, which is an important implication for clinical and research purposes.
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影响因子：
4.4
作者：
Hood, Donald C.;Tsamis, Emmanouil;De Moraes, Carlos G.
通讯作者：
De Moraes, Carlos G.
影响因子：
13.7
作者：
Chen, Teresa C.;Hoguet, Ambika;Chen, Philip P.
通讯作者：
Chen, Philip P.
影响因子：
--
作者：
ASMAN, P;HEIJL, A
通讯作者：
HEIJL, A
影响因子：
17.8
作者：
Hood DC;Raza AS;de Moraes CG;Liebmann JM;Ritch R
通讯作者：
Ritch R
影响因子：
4.4
作者：
Kim, Na Rae;Lee, Eun Suk;Kim, Chan Yun
通讯作者：
Kim, Chan Yun