Integration of non-vesicular and vesicular transport processes at the Golgi complex by the PKD-CERT network.

Integration of non-vesicular and vesicular transport processes at the Golgi complex by the PKD-CERT network.
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PKD-CERT 网络整合高尔基复合体的非囊泡和囊泡运输过程

DOI:
10.1016/j.bbalip.2011.12.005
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发表时间:
2012
期刊:
Biochimica et biophysica acta
影响因子:
--
通讯作者:
Hausser
Hausser
中科院分区:
--
文献类型:
--
作者:
Olayioye;Hausser

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神经酰胺从内质网到高尔基体膜的非囊泡转运对于细胞脂质稳态是必不可少的。蛋白激酶D(PKD)是一种丝氨酸-苏氨酸激酶,控制高尔基体膜上的囊泡分裂。在这里,我们强调了高尔基复合体水平上非囊泡和囊泡转运之间的密切联系,并表明PKD及其底物CERT(神经酰胺转移蛋白)通过微调局部膜脂质组成来协调这些过程,在协调这些过程中发挥着核心作用。维持高尔基体分泌功能。这篇文章是题为脂质和囊泡运输的特刊的一部分。
Non-vesicular transport of ceramide from endoplasmic reticulum to Golgi membranes is essential for cellular lipid homeostasis. Protein kinase D (PKD) is a serine–threonine kinase that controls vesicle fission at Golgi membranes. Here we highlight the intimate connections between non-vesicular and vesicular transport at the level of the Golgi complex, and suggest that PKD and its substrate CERT, the ceramide transfer protein, play central roles in coordinating these processes by fine-tuning the local membrane lipid composition to maintain Golgi secretory function. This article is part of a Special Issue entitled Lipids and Vesicular Transport.
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