Integration of non-vesicular and vesicular transport processes at the Golgi complex by the PKD-CERT network.
Integration of non-vesicular and vesicular transport processes at the Golgi complex by the PKD-CERT network.
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PKD-CERT 网络整合高尔基复合体的非囊泡和囊泡运输过程
DOI:
10.1016/j.bbalip.2011.12.005
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发表时间:
2012
期刊:
影响因子:
--
通讯作者:
Hausser
中科院分区:
文献类型:
--
作者:
Olayioye;Hausser
Non-vesicular transport of ceramide from endoplasmic reticulum to Golgi membranes is essential for cellular lipid homeostasis. Protein kinase D (PKD) is a serine–threonine kinase that controls vesicle fission at Golgi membranes. Here we highlight the intimate connections between non-vesicular and vesicular transport at the level of the Golgi complex, and suggest that PKD and its substrate CERT, the ceramide transfer protein, play central roles in coordinating these processes by fine-tuning the local membrane lipid composition to maintain Golgi secretory function. This article is part of a Special Issue entitled Lipids and Vesicular Transport.
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