Adalimumab Biosimilar-Induced Severe Paradoxical Palmoplantar Pustulosis in a Patient with Psoriasis and Psoriatic Arthritis Successfully Treated with Ixekizumab.
Adalimumab Biosimilar-Induced Severe Paradoxical Palmoplantar Pustulosis in a Patient with Psoriasis and Psoriatic Arthritis Successfully Treated with Ixekizumab.
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DOI：
10.1007/s13555-021-00672-z
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发表时间：
2022-03
影响因子：
3.4
通讯作者：
Tivadar S
中科院分区：
文献类型：
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作者：
Gkalpakiotis S;Fridman M;Tivadar S
寻常型银屑病是一种慢性免疫介导的炎症性皮肤病。生物治疗已经有10多年的历史，已经成为中重度银屑病患者的标准治疗方法之一。最初，仅使用针对肿瘤坏死因子α（TNF-α）的生物制剂，直到后来才有针对不同白细胞介素（IL-17或IL-23）的药物可用。生物治疗的副作用包括反常不良事件（PAEs），如掌跖脓疱反应，尤其是抗TNF-α药物。我们报告了一例49岁女性糖尿病、银屑病和银屑病关节炎患者，该患者接受阿达木单抗生物类似药治疗后发生掌跖脓疱型重度PAE。停止阿达木单抗治疗，患者改用ixekizumab，并取得成功。当在生物治疗期间出现矛盾反应时，特别是当它像我们的患者一样严重时，建议改用另一类生物制剂。
Psoriasis vulgaris is a chronic immune-mediated inflammatory disease of the skin. Biologic therapy has been available for more than 10 years and has become one of the standard treatments for patients with moderate to severe psoriasis. Initially, only biologics against tumour necrosis factor alpha (TNF-α) were used, and only later did drugs against different interleukins (ILs), including IL-17 or IL-23, became available. The side effects of biologic therapy include paradoxical adverse events (PAEs), such as palmoplantar pustular reaction, especially with anti-TNF-α drugs. We present the case of a 49-year-old female patient with diabetes and psoriasis and psoriatic arthritis treated with an adalimumab biosimilar who developed a severe PAE of the palmoplantar pustular type. Treatment with adalimumab was stopped and the patient switched to ixekizumab which was successful. When a paradoxical reaction develops during biologic therapy, especially when it is severe as in our patient, switching to another class of biologics is advised.
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影响因子：
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作者：
Ma, Hak-Ling;Napierata, Lee;Young, Deborah A.
通讯作者：
Young, Deborah A.
影响因子：
24.5
作者：
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影响因子：
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DOI：
10.1159/000479475
发表时间：
2018-01-01
期刊：
Current problems in dermatology
影响因子：
--
作者：
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通讯作者：
Puig, Lluis
影响因子：
3.4
作者：
Armstrong AW;Soliman AM;Betts KA;Wang Y;Gao Y;Puig L;Augustin M
通讯作者：
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