FUT2 Genetic Variants and Reported Respiratory and Gastrointestinal Illnesses During Infancy.
FUT2 Genetic Variants and Reported Respiratory and Gastrointestinal Illnesses During Infancy.
复制标题
DOI：
10.1093/infdis/jiy582
复制
发表时间：
2019-02-15
期刊：
影响因子：
--
通讯作者：
Binia A
中科院分区：
文献类型：
--
作者：
Barton SJ;Murray R;Lillycrop KA;Inskip HM;Harvey NC;Cooper C;Karnani N;Zolezzi IS;Sprenger N;Godfrey KM;Binia A
FUT 2控制参与病原体附着的组织血型抗原在消化和呼吸上皮上的产生。我们研究的目的是将FUT 2变异体与婴儿期胃肠道和呼吸道疾病报告相关。在英国南安普顿妇女调查中，对1831名婴儿进行了FUT 2遗传变异（rs601338，rs602662）基因分型，并与调整性别，母乳喂养持续时间和潜在混杂因素后的婴儿疾病相关。对于FUT 2 SNP rs601338，每个额外风险（G）等位基因在6-12和12-24个月时发生≥1次腹泻的风险比为1.23（95%CI 1.08-1.4，p=0.002）和1.41（1.24-1.61 p= 1.7 × 10 ~（-7））; ≥1例下呼吸道疾病诊断的风险比每增加一个G等位基因，12-24个月时的肺炎或细支气管炎发病率为2.66（1.64-4.3，p=0.00007）。由于与rs601338的高度连锁不平衡（R2=0.92），在rs602662与胃肠道和呼吸道疾病之间也发现了类似的关联。母乳喂养时间越长，腹泻风险越低，与婴儿FUT 2基因型无关。我们证实FUT 2 G等位基因与婴儿胃肠道疾病的高风险相关，并确定了与呼吸系统疾病的新关联。FUT 2基因座变异需要在未来的婴儿胃肠道和呼吸道疾病的研究中加以考虑。
FUT2 controls the production on digestive and respiratory epithelia of histo-blood group antigens involved in the attachment of pathogens. The aim of our study was to relate FUT2 variants to reported gastrointestinal and respiratory illnesses in infancy. In the UK Southampton Women’s Survey, FUT2 genetic variants (rs601338, rs602662) were genotyped in 1831 infants and related to infant illnesses adjusting for sex, breastfeeding duration and potential confounders. For FUT2 SNP rs601338, the risk ratios for ≥1 bout of diarrhoea from ages 6-12 and 12-24 months per additional risk (G) allele were 1.23 (95%CI 1.08-1.4, p=0.002) and 1.41 (1.24-1.61 p=1.7x10-7), respectively; the risk ratio for ≥1 diagnoses of lower respiratory illnesses (pneumonia or bronchiolitis) from 12-24 months per additional G allele was 2.66 (1.64-4.3, p=0.00007). Similar associations were found between rs602662 and gastrointestinal and respiratory illnesses, due to the high linkage disequilibrium with rs601338 (R2=0.92). Longer breastfeeding duration predicted a lower risk of diarrhoea independent of infant FUT2 genotype. We confirmed that FUT2 G-alleles are associated with a higher risk of infant gastrointestinal illnesses and identified novel associations with respiratory illnesses. FUT2 locus variants need consideration in future studies of infantile gastrointestinal and respiratory illnesses.
登录
查看更多内容
影响因子：
12.3
作者：
Kolde R;Franzosa EA;Rahnavard G;Hall AB;Vlamakis H;Stevens C;Daly MJ;Xavier RJ;Huttenhower C
通讯作者：
Huttenhower C
影响因子：
5.4
作者：
Liu, Yang;Huang, Pengwei;Jiang, Xi
通讯作者：
Jiang, Xi
影响因子：
3
作者：
Silva, Lara M.;Carvalho, Ana S.;David, Leonor
通讯作者：
David, Leonor
影响因子：
4.1
作者：
Serpa, J;Mendes, N;David, L
通讯作者：
David, L
DOI：
10.1016/s0140-6736(17)30938-8
发表时间：
2017-09-02
期刊：
Lancet (London, England)
影响因子：
--
作者：
Shi T;McAllister DA;O'Brien KL;Simoes EAF;Madhi SA;Gessner BD;Polack FP;Balsells E;Acacio S;Aguayo C;Alassani I;Ali A;Antonio M;Awasthi S;Awori JO;Azziz-Baumgartner E;Baggett HC;Baillie VL;Balmaseda A;Barahona A;Basnet S;Bassat Q;Basualdo W;Bigogo G;Bont L;Breiman RF;Brooks WA;Broor S;Bruce N;Bruden D;Buchy P;Campbell S;Carosone-Link P;Chadha M;Chipeta J;Chou M;Clara W;Cohen C;de Cuellar E;Dang DA;Dash-Yandag B;Deloria-Knoll M;Dherani M;Eap T;Ebruke BE;Echavarria M;de Freitas Lázaro Emediato CC;Fasce RA;Feikin DR;Feng L;Gentile A;Gordon A;Goswami D;Goyet S;Groome M;Halasa N;Hirve S;Homaira N;Howie SRC;Jara J;Jroundi I;Kartasasmita CB;Khuri-Bulos N;Kotloff KL;Krishnan A;Libster R;Lopez O;Lucero MG;Lucion F;Lupisan SP;Marcone DN;McCracken JP;Mejia M;Moisi JC;Montgomery JM;Moore DP;Moraleda C;Moyes J;Munywoki P;Mutyara K;Nicol MP;Nokes DJ;Nymadawa P;da Costa Oliveira MT;Oshitani H;Pandey N;Paranhos-Baccalà G;Phillips LN;Picot VS;Rahman M;Rakoto-Andrianarivelo M;Rasmussen ZA;Rath BA;Robinson A;Romero C;Russomando G;Salimi V;Sawatwong P;Scheltema N;Schweiger B;Scott JAG;Seidenberg P;Shen K;Singleton R;Sotomayor V;Strand TA;Sutanto A;Sylla M;Tapia MD;Thamthitiwat S;Thomas ED;Tokarz R;Turner C;Venter M;Waicharoen S;Wang J;Watthanaworawit W;Yoshida LM;Yu H;Zar HJ;Campbell H;Nair H;RSV Global Epidemiology Network
通讯作者：
RSV Global Epidemiology Network