Effect of selective vaccination on a decrease in the rate of hepatitis B virus‐positive Japanese first‐time blood donors
Effect of selective vaccination on a decrease in the rate of hepatitis B virus‐positive Japanese first‐time blood donors
复制标题
选择性疫苗接种对降低日本首次献血者乙型肝炎病毒阳性率的影响
DOI：
10.1111/j.1365-3148.2009.00930.x
复制
发表时间：
2009
影响因子：
1.5
通讯作者：
K. Tadokoro
中科院分区：
文献类型：
--
作者：
A. Yoshikawa;K. Suzuki;A. Abe;T. Tanaka;K. Yamaguchi;T. Tanaka;Y. Ishikawa;K. Minegishi;Y. Gotanda;H. Yugi;S. Uchida;M. Satake;H. Mizoguchi;K. Tadokoro
自1986年1月以来，日本政府开始实施选择性疫苗接种计划，以预防B型肝炎病毒（HBV）的母婴感染。该计划对首次献血者的影响尚未详细研究。从日本红十字会（JRC）献血者数据库中提取1996年至2007年16-25岁首次献血者的数据。主成分分析（PCA）用于显示HBV阳性供体率的出生年份依赖组。按出生年份将供体按PCA分为4组。该计划开始后，1986-1989年出生的捐赠者组成了一个群体。在方案开始之前，确定了三个组（1980年、1981-1984年和1985年）。尽管在项目开始前观察到HBV阳性献血者的比例呈时间依赖性显著下降，但通过对16-19岁首次献血者进行回归分析，在项目开始前后观察到HBV阳性献血者的比例存在显著差异。从首次献血者的分析来看，选择性疫苗接种计划有效预防了HBV的垂直传播。另一方面，应考虑对献血者进行疫苗接种，以降低输血后HBV感染的风险，因为HBV阳性献血者的水平传播增加。
The government of Japan started a selective vaccination programme to prevent mother‐to‐infant infection by hepatitis B virus (HBV) since January 1986. The effect of the programme on first‐time blood donors has not been examined in detail. Data of first‐time blood donors aged 16–25 years from 1996 to 2007 were extracted from the Japanese Red Cross (JRC) donors' database. Principal component analysis (PCA) was used to visualize the birth‐year‐dependent group of rate of HBV‐positive donors. According to the birth of year, donors were divided into four groups by PCA. After the start of the programme, donors born in 1986–1989 comprised a single group. Before the start of the programme, three groups (1980, 1981–1984 and 1985) were identified. Although a significant time‐dependent decrease in the rate of HBV‐positive donors was observed before the start of the programme, a significant difference in the rate of HBV‐positive donors was observed around the start of the programme by regression analysis for 16–19‐year‐old first‐time blood donors. The selective vaccination programme has been effective to prevent the vertical transmission of HBV from the analysis of first‐time blood donors. On the other hand, vaccination of blood donors should be considered to reduce the risk of post‐transfusion HBV infection, because the horizontal transmission increases in HBV‐positive blood donors.
日本急性乙型肝炎患者乙型肝炎病毒基因型的空间和时间差异。
DOI：
--
发表时间：
2006
期刊：
Hepatology Research 36
影响因子：
--
作者：
Sugauchi F;et al.
通讯作者：
et al.
影响因子：
13.5
作者：
Orito, E;Ichida, T;Mizokami, M
通讯作者：
Mizokami, M