Structure and medium effects on hydraphile synthetic ion channel toxicity to the bacterium E. coli
Structure and medium effects on hydraphile synthetic ion channel toxicity to the bacterium E. coli
复制标题
结构和介质对亲水合成离子通道对大肠杆菌的毒性的影响
DOI：
10.1039/b413048k
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发表时间：
2005
影响因子：
3.3
通讯作者：
G. Gokel
中科院分区：
文献类型：
--
作者：
W. Leevy;Michael R Gokel;George B. Hughes;Paul H. Schlesinger;G. Gokel
在侧臂位置系统地改变合成的亲水通道，并在中性和酸性条件下针对革兰氏阴性菌E.杆菌侧臂结构是双分子层内通道活性的关键决定因素，并极大地影响毒性。的生物活性数据相关性非常好的Na+运输研究的结果，使用合成脂质体系统。在中性和酸性条件下进行实验以确定最小抑菌浓度（MIC）。与在pH = 107时相比，在pH = 5.5时亲水体毒性降低，提供了pH依赖性合成非肽离子通道的实例。
Synthetic hydraphile channels were systematically varied at the side arm position and tested under neutral and acidic conditions against the Gram-negative bacterium E. coli. Side arm structure is a critical determinant of channel activity within the bilayer and greatly influences toxicity. The biological activity data correlate remarkably well with the results of Na+ transport studies conducted using synthetic liposome systems. Experiments to determine minimum inhibitory concentrations (MIC) were conducted under both neutral and acidic conditions. Hydraphile toxicity was diminished at pH = 5.5, compared to that at pH = ∼7, providing an example of a pH-dependent, synthetic, non-peptide ion channel.
影响因子：
3.5
作者：
G. Gokel;Paul H. Schlesinger;N. Djedovic;R. Ferdani;Egan Harder;Jiaxing Hu;W. Leevy;Jolanta Pajewska;Robert Pajewski;Michelle E. Weber
通讯作者：
G. Gokel;Paul H. Schlesinger;N. Djedovic;R. Ferdani;Egan Harder;Jiaxing Hu;W. Leevy;Jolanta Pajewska;Robert Pajewski;Michelle E. Weber
影响因子：
15
作者：
Leevy, WM;Donato, GM;Gokel, GW
通讯作者：
Gokel, GW