Timed daily exercise remodels circadian rhythms in mice.
Timed daily exercise remodels circadian rhythms in mice.
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DOI：
10.1038/s42003-021-02239-2
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发表时间：
2021-06-18
影响因子：
5.9
通讯作者：
Piggins HD
中科院分区：
文献类型：
--
作者：
Hughes ATL;Samuels RE;Baño-Otálora B;Belle MDC;Wegner S;Guilding C;Northeast RC;Loudon ASI;Gigg J;Piggins HD
经常锻炼对身心健康很重要。运动的一个未被研究和有趣的特性是它对身体24 h或昼夜节律的作用。大脑视交叉上核(SCN)中的分子时钟细胞使用电子和化学信号来协调它们的活动，并将一天中的时间信息传递给大脑和身体的其他部分。到目前为止，有规律的体育锻炼对SCN时钟细胞协调和交流的长期影响仍然没有解决。利用SCN细胞间神经肽信号转导受损的小鼠模型和SCN神经化学信号转导完整的小鼠模型，我们研究了日常计划的自愿锻炼(SVE)对行为节律和SCN分子和神经元活动的影响。我们发现，在神经肽信号转导中断的小鼠中，SVE促进了SCN时钟细胞的同步性和强大的24 h行为节律。有趣的是，在完整和神经肽信号缺陷的动物中，SVE降低了SCN的神经活性，并改变了GABA能信号。这些发现表明，在老年人或精神病患者中，定期锻炼作为一种长期有效的非侵入性干预措施的潜在效用，在这些患者中，昼夜节律可能变得迟钝，与外部世界难以协调。Hughes等人使用神经肽信号转导中断的小鼠。结果表明，每日计划的自愿锻炼可促进视交叉上核时钟细胞的同步性和24 h的行为节律。这项研究表明，对于老年人或精神病患者，定期锻炼作为一种非侵入性干预措施的潜在效用，这些人的昼夜节律可能与外部世界不太一致。
Regular exercise is important for physical and mental health. An underexplored and intriguing property of exercise is its actions on the body’s 24 h or circadian rhythms. Molecular clock cells in the brain’s suprachiasmatic nuclei (SCN) use electrical and chemical signals to orchestrate their activity and convey time of day information to the rest of the brain and body. To date, the long-lasting effects of regular physical exercise on SCN clock cell coordination and communication remain unresolved. Utilizing mouse models in which SCN intercellular neuropeptide signaling is impaired as well as those with intact SCN neurochemical signaling, we examined how daily scheduled voluntary exercise (SVE) influenced behavioral rhythms and SCN molecular and neuronal activities. We show that in mice with disrupted neuropeptide signaling, SVE promotes SCN clock cell synchrony and robust 24 h rhythms in behavior. Interestingly, in both intact and neuropeptide signaling deficient animals, SVE reduces SCN neural activity and alters GABAergic signaling. These findings illustrate the potential utility of regular exercise as a long-lasting and effective non-invasive intervention in the elderly or mentally ill where circadian rhythms can be blunted and poorly aligned to the external world. Using mice with disrupted neuropeptide signaling, Hughes et al. show that daily scheduled voluntary exercise (SVE) promotes suprachiasmatic nuclei (SCN) clock cell synchrony and robust 24 h rhythms in behavior. This study suggests the potential utility of regular exercise as a non-invasive intervention for the elderly or mentally ill, where circadian rhythms can be poorly aligned to the external world.
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影响因子：
16.2
作者：
Evans JA;Leise TL;Castanon-Cervantes O;Davidson AJ
通讯作者：
Davidson AJ
影响因子：
3.3
作者：
Belenky, MA;Sagiv, N;Yarom, Y
通讯作者：
Yarom, Y
DOI：
10.1073/pnas.1319820111
发表时间：
2014-07-01
影响因子：
11.1
作者：
Farajnia, Sahar;van Westering, Tirsa L. E.;Michel, Stephan
通讯作者：
Michel, Stephan
影响因子：
5.3
作者：
Choi, Hee Joo;Lee, C. Justin;Kim, Yang In
通讯作者：
Kim, Yang In
影响因子：
3.4
作者：
Dragich, Joanna M.;Loh, Dawn H.;Colwell, Christopher S.
通讯作者：
Colwell, Christopher S.