The human and canine TERT promoters function equivalently in human and canine cells.
The human and canine TERT promoters function equivalently in human and canine cells.
复制标题
人和犬的 TERT 启动子在人和犬细胞中的功能相同。
DOI：
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复制
发表时间：
2010
影响因子：
2.1
通讯作者：
I. Morgan
中科院分区：
文献类型：
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作者：
M. Arendt;L. Nasir;I. Morgan
以端粒酶为靶点的肿瘤基因治疗正在被开发用于治疗人类肿瘤。人类和犬癌症的高发病率和许多比较方面以及狗主人治疗癌症的依从性和奉献精神使犬宠物群体成为研究和开发新癌症疗法的良好临床模型。在这里，我们报告了人端粒酶启动子在犬细胞中的作用，这表明人端粒酶启动子驱动的癌症治疗可用于治疗犬的癌症。因此，犬类宠物群体可以作为基于端粒酶疗法的新药开发的临床模型。
Telomerase targeted cancer gene therapy is being exploited for treatment of human cancer. The high incidence and many comparative aspects of human and canine cancer and the compliance and dedication of dog owners to treat cancer makes the canine pet population a good clinical model for investigating and developing new cancer therapeutics. Here, we report that the human telomerase promoter operates in canine cells, suggesting that human telomerase promoter-driven cancer therapy can be used to treat cancer in canines. Therefore, the canine pet population can act as a clinical model for new drug development based on telomerase therapeutics.
影响因子：
56.9
作者：
KIM, NW;PIATYSZEK, MA;SHAY, JW
通讯作者：
SHAY, JW
患有晚期恶性黑色素瘤的狗在接种异种人酪氨酸酶 DNA 疫苗后长期存活：I 期试验。
DOI：
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发表时间：
2003
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
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作者：
Bergman,PhilipJ;McKnight,Joanne;Novosad,Andrew;Charney,Sarah;Farrelly,John;Craft,Diane;Wulderk,Michelle;Jeffers,Yusuf;Sadelain,Michel;Hohenhaus,AnnE;Segal,Neil;Gregor,Polly;Engelhorn,Manuel;Riviere,Isabelle;Houghton,AlanN;
通讯作者：
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