Evaluation of heparinized syringes for measuring newborn metabolites in neonates with a central arterial line.
Evaluation of heparinized syringes for measuring newborn metabolites in neonates with a central arterial line.
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DOI：
10.1016/j.clinbiochem.2021.10.007
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发表时间：
2022-01
影响因子：
2.8
通讯作者：
Jelliffe-Pawlowski LL
中科院分区：
文献类型：
--
作者：
Ryckman KK;Ramesh A;Cho H;Oltman SP;Rogers EE;Dagle JM;Jelliffe-Pawlowski LL
新生儿代谢筛查是一种新的方法，用于预测新生儿发病率和死亡率非常早产儿（<32周妊娠）。我们研究的目的是确定通过电解质平衡的干肝素锂注射器采集的血液（作为血气测量的常规方法）是否会影响目标代谢物和生物标志物水平。同时从20名具有中心动脉管路的婴儿中采集两份血液样本（一份使用肝素化注射器采集，另一份使用非肝素化注射器采集），并使用新生儿筛查的标准程序检测49种代谢物和生物标志物。总体而言，不同注射器类型的中位代谢物水平无显著差异。然而，个体配对样本存在广泛的变异性，特别是氨基酸和免疫反应性胰蛋白酶原，因此，在新生儿发病率和死亡率的预测模型中使用这些代谢物时，应考虑样本采集。
Newborn metabolic screening is emerging as a novel method for predicting neonatal morbidity and mortality in neonates born very preterm (<32 weeks gestation). The purpose of our study was to determine if blood collected by an electrolyte-balanced dry lithium heparin syringe, as is routine for blood gas measurements, affects targeted metabolite and biomarker levels. Two blood samples (one collected with a heparinized syringe and the other with a non-heparinized syringe) were obtained at the same time from 20 infants with a central arterial line and tested for 49 metabolites and biomarkers using standard procedures for newborn screening. Overall, the median metabolite levels did not significantly differ by syringe type. However, there was wide variability, particularly for amino acids and immunoreactive trypsinogen, for individual paired samples and therefore, consideration should be given to sample collection when using these metabolites in prediction models of neonatal morbidity and mortality.
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影响因子：
3.7
作者：
Kennedy AD;Ford L;Wittmann B;Conner J;Wulff J;Mitchell M;Evans AM;Toal DR
通讯作者：
Toal DR
DOI：
10.1016/j.jpeds.2018.03.032
发表时间：
2018-07
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Oltman SP;Rogers EE;Baer RJ;Anderson JG;Steurer MA;Pantell MS;Partridge JC;Rand L;Ryckman KK;Jelliffe-Pawlowski LL
通讯作者：
Jelliffe-Pawlowski LL
影响因子：
2
作者：
GAYED, AM;MARINO, ME;DOLANSKI, EA
通讯作者：
DOLANSKI, EA
影响因子：
9.8
作者：
Ryckman KK;Berberich SL;Dagle JM
通讯作者：
Dagle JM
DOI：
10.4103/0972-5229.125428
发表时间：
2014-01
期刊：
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
影响因子：
--
作者：
Chhapola V;Kumar S;Goyal P
通讯作者：
Goyal P