Induction of prolonged natural lifespans in mice exposed to acoustic environmental enrichment.

Induction of prolonged natural lifespans in mice exposed to acoustic environmental enrichment.
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DOI:
10.1038/s41598-018-26302-x
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发表时间:
2018-05-21
期刊:
影响因子:
4.6
通讯作者:
Honda M
Honda M
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Yamashita Y;Kawai N;Ueno O;Matsumoto Y;Oohashi T;Honda M

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我们研究了声学环境富集(EE)对小鼠寿命和行为的影响,直到它们在不同声学环境中的自然寿命结束。声学EE诱导了显著延长的自然寿命(延长近17%),并与自愿运动增加有关。然而,没有检测到寿命和自愿运动之间的相关性,这表明增加自愿运动不是寿命延长的主要原因。对寿命个体差异的分析表明,由声学EE引起的寿命延长可能与社会关系的变化有关(例如,减少社会冲突)。因此,声学组件可能是诱发EE的积极效果的重要因素。
We investigated the effect of acoustic environmental enrichment (EE) on the lifespans and behaviours of mice to the end of their natural lifespan in different acoustic environments. Acoustic EE induced a significantly prolonged natural lifespan (nearly 17% longer) and was associated with increased voluntary movements. However, no correlation between lifespan and voluntary movements was detected, suggesting that increased voluntary movements are not a primary cause of lifespan prolongation. Analyses of individual differences in lifespan demonstrated that lifespan extension induced by acoustic EE could be related to changes in social relationships (e.g., reduction of social conflict) among individuals kept within a cage. Therefore, an acoustic component may be an important factor inducing the positive effects of EE.
听不清的高频的频率听起来会差异地影响大脑活动:积极和负性超声效应。
DOI: 10.1371/journal.pone.0095464
发表时间: 2014
期刊: PloS one
影响因子: 3.7
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