Induction of prolonged natural lifespans in mice exposed to acoustic environmental enrichment.
Induction of prolonged natural lifespans in mice exposed to acoustic environmental enrichment.
复制标题
DOI:
10.1038/s41598-018-26302-x
复制
发表时间:
2018-05-21
影响因子:
4.6
通讯作者:
Honda M
中科院分区:
文献类型:
--
作者:
Yamashita Y;Kawai N;Ueno O;Matsumoto Y;Oohashi T;Honda M
We investigated the effect of acoustic environmental enrichment (EE) on the lifespans and behaviours of mice to the end of their natural lifespan in different acoustic environments. Acoustic EE induced a significantly prolonged natural lifespan (nearly 17% longer) and was associated with increased voluntary movements. However, no correlation between lifespan and voluntary movements was detected, suggesting that increased voluntary movements are not a primary cause of lifespan prolongation. Analyses of individual differences in lifespan demonstrated that lifespan extension induced by acoustic EE could be related to changes in social relationships (e.g., reduction of social conflict) among individuals kept within a cage. Therefore, an acoustic component may be an important factor inducing the positive effects of EE.
登录
查看更多内容
影响因子:
3.7
作者:
Fukushima A;Yagi R;Kawai N;Honda M;Nishina E;Oohashi T
通讯作者:
Oohashi T
影响因子:
3.7
作者:
Matsumoto YK;Okanoya K
通讯作者:
Okanoya K
DOI:
10.1016/j.jalz.2009.02.006
发表时间:
2009-07
期刊:
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子:
--
作者:
Nichol K;Deeny SP;Seif J;Camaclang K;Cotman CW
通讯作者:
Cotman CW
影响因子:
5.3
作者:
Rochefort, C;Gheusi, G;Lledo, PM
通讯作者:
Lledo, PM
影响因子:
3.3
作者:
de Groot, J;van Milligen, FJ;Koolhaas, JM
通讯作者:
Koolhaas, JM