Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis.
Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis.
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DOI：
10.1038/s41598-021-86064-x
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发表时间：
2021-03-22
影响因子：
4.6
通讯作者：
Karsdal MA
中科院分区：
文献类型：
--
作者：
Bay-Jensen AC;Bihlet A;Byrjalsen I;Andersen JR;Riis BJ;Christiansen C;Michaelis M;Guehring H;Ladel C;Karsdal MA
骨关节炎（OA）的异质性和对患者亚型的需要在该领域被广泛接受。生物标志物CRPM是c反应蛋白（CRP）的代谢物，在炎症期间释放到循环中。血液CRPM水平已被证明与类风湿性关节炎（RA）的疾病活动性和治疗反应相关。我们使用两项III期膝关节OA和两项RA研究（N = 1591）的数据，研究了OA患者与RA患者的血液CRPM水平。此外，研究了CRPM水平与影像学进展之间的关系。OA患者的平均CRPM水平（8.5 [95% CI 8.3-8.8] ng/mL, n = 781）显著低于RA患者（12.8 [9.5-16.0]ng/mL, n = 60）；然而，相当一部分OA患者（31%）的CRPM水平（≥9 ng/mL）与RA相当。此外，在两年的随访期间，通过x线评估，CRPM水平≥9 ng/mL的OA患者（n = 152）更有可能发展为对侧膝关节OA，比值比为2.2[1.0-4.7]。这些数据表明，CRPM是一种基于血液的生化标志物，可用于早期识别OA患者的炎症表型。
The heterogeneous nature of osteoarthritis (OA) and the need to subtype patients is widely accepted in the field. The biomarker CRPM, a metabolite of C-reactive protein (CRP), is released to the circulation during inflammation. Blood CRPM levels have shown to be associated with disease activity and response to treatment in rheumatoid arthritis (RA). We investigated the level of blood CRPM in OA compared to RA using data from two phase III knee OA and two RA studies (N = 1591). Moreover, the association between CRPM levels and radiographic progression was investigated. The mean CRPM levels were significantly lower in OA (8.5 [95% CI 8.3–8.8] ng/mL, n = 781) compared to the RA patients (12.8 [9.5–16.0] ng/mL, n = 60); however, a significant subset of OA patients (31%) had CRPM levels (≥ 9 ng/mL) comparable to RA. Furthermore, OA patients (n = 152) with CRPM levels ≥ 9 ng/mL were more likely to develop contra-lateral knee OA assessed by X-ray over a two-year follow-up period with an odds ratio of 2.2 [1.0–4.7]. These data suggest that CRPM is a blood-based biochemical marker for early identification OA patients with an inflammatory phenotype.
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影响因子：
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作者：
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7.6
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通讯作者：
Krag A