Endogenous human brain dynamics recover slowly following cognitive effort.
Endogenous human brain dynamics recover slowly following cognitive effort.
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DOI：
10.1371/journal.pone.0006626
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发表时间：
2009-08-14
期刊：
影响因子：
3.7
通讯作者：
Suckling J
中科院分区：
文献类型：
--
作者：
Barnes A;Bullmore ET;Suckling J
在功能性磁共振成像中，大脑对实验操作的反应几乎总是被认为独立于内源性振荡以测试这一点，我们解决了认知任务性能与内源性FMRI振荡之间可能的相互作用。 ）与在任务之前的值相比性能？
使用一种新型的连续采集“休息任务”设计，我们发现内源性动力学倾向于在几分钟内恢复其前任务参数值相对较慢，在完成了两个版本之一之后 - 返回工作内存任务，并且在任务的苛刻（n = 2）版本完成后，恢复率较慢。
该结果支持了内源性低频振荡动力学与大脑对外源刺激的反应有关的模型。可以花费大量时间返回稳定的基线状态。
In functional magnetic resonance imaging, the brain's response to experimental manipulation is almost always assumed to be independent of endogenous oscillations. To test this, we addressed the possible interaction between cognitive task performance and endogenous fMRI oscillations in an experiment designed to answer two questions: 1) Does performance of a cognitively effortful task significantly change fractal scaling properties of fMRI time series compared to their values before task performance? 2) If so, can we relate the extent of task-related perturbation to the difficulty of the task? Using a novel continuous acquisition “rest-task-rest” design, we found that endogenous dynamics tended to recover their pre-task parameter values relatively slowly, over the course of several minutes, following completion of one of two versions of the n-back working memory task and that the rate of recovery was slower following completion of the more demanding (n = 2) version of the task. This result supports the model that endogenous low frequency oscillatory dynamics are relevant to the brain's response to exogenous stimulation. Moreover, it suggests that large-scale neurocognitive systems measured using fMRI, like the heart and other physiological systems subjected to external demands for enhanced performance, can take a considerable period of time to return to a stable baseline state.
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