Adverse childhood experiences and early life inflammation in the Avon longitudinal study of parents and children.
Adverse childhood experiences and early life inflammation in the Avon longitudinal study of parents and children.
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DOI：
10.1016/j.psyneuen.2020.104914
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发表时间：
2020-12
影响因子：
3.7
通讯作者：
Howe LD
中科院分区：
文献类型：
--
作者：
Lacey RE;Bartley M;Kelly-Irving M;Bevilacqua L;Iob E;Kelly Y;Howe LD
在ACE研究中，存在对ACE评分和单一逆境方法的依赖。我们比较了ACE评分、个体ACE和早期炎症的潜在类别分析（LCA）。LCA确定了四个集群。“母亲心理健康问题”与女孩的CRP较低有关。父母离婚的IL-6较高，情绪虐待，父亲心理健康问题，父母犯罪和酒精滥用的IL-6较低。父亲的心理健康问题和情绪虐待与较低的IL-6之间的关联只见于男孩。不良童年经历（ACE）与整个生命过程中的健康状况较差有关。以前的研究使用累积风险评分（ACE评分）或个体ACE，但这两种方法有重要的缺点。ACE分数假设每个逆境对利益的结果同样重要，而单一逆境方法假设ACE不会同时发生。潜在类别分析（LCA）是一种可操作ACE数据的替代方法，可识别共同报告类似ACE的人群。在这里，我们将这三种方法应用于儿童期炎症的ACE操作，目的是确定与早期炎症特别相关的特定ACE或ACE组合。使用雅芳父母和儿童纵向研究（ALSPAC）的数据，我们比较ACE评分，单一逆境和LCA衍生的ACE簇与9岁时的白细胞介素-6（n = 4935）和9岁时的C-反应蛋白（CRP）（n = 4887）的关系。ACE包括父母分居/离婚，父母酗酒问题，父母心理健康问题，父母犯罪，父母间暴力，父母滥用药物，身体，情感和性虐待。三分之二的样本报告至少有一个ACE。母亲的精神健康问题是最常见的ACE（32.3%）。LCA确定了四种ACE类别-"低ACE"（81.1%），"孕产妇心理健康问题"（10.3%），"孕产妇心理健康问题和身体虐待"（6.3%）和"父母冲突，心理健康问题和情感虐待"（2.4%）。父母分居/离婚与较高的IL-6相关。父母的酒精问题，父亲的心理健康问题，父母的信念和情感虐待与较低水平的IL-6。父亲的心理健康问题和情感虐待的协会只观察到男孩。ACE评分和LCA衍生的ACE分类与IL-6的差异无关。"孕产妇心理健康问题"组中的女孩CRP水平较低。特定的逆境和逆境组合对儿童炎症的差异很重要。一些协会只观察到女孩或男孩。
There is a reliance on ACE scores and single adversity approaches in ACEs research. We compare ACE scores, individual ACEs and latent class analysis (LCA) for early life inflammation. LCA identified four clusters. ‘Maternal mental health problems’ was associated with lower CRP for girls. IL-6 was higher for parental divorce and lower for emotional abuse, paternal mental health problems, parental offending and alcohol misuse. Associations between paternal mental health problems and emotional abuse with lower IL-6 were only seen for boys. Adverse childhood experiences (ACEs) have been associated with poorer health across the life course. Previous studies have used cumulative risk scores (ACE scores) or individual ACEs but these two approaches have important shortcomings. ACE scores assume that each adversity is equally important for the outcome of interest and the single adversity approach assumes that ACEs do not co-occur. Latent class analysis (LCA) is an alternative approach to operationalising ACEs data, identifying groups of people co-reporting similar ACEs. Here we apply these three approaches for ACEs operationalisation with inflammation in childhood with the aim of identifying particular ACEs or ACE combinations that are particularly associated with higher inflammation in early life. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) we compare ACE scores, single adversities and LCA-derived ACE clusters in their relationships with Interleukin-6 at age 9 (n = 4935) and C-Reactive Protein (CRP) at age 9 (n = 4887). ACEs included were parental separation/divorce, parental alcohol problems, parental mental health problems, parental offending, inter-parental violence, parental drug misuse, and physical, emotional and sexual abuse. Two thirds of the sample reported at least one ACE. Mother’s mental health problems was the most frequently reported ACE (32.3 %). LCA identified four ACE classes – ‘Low ACEs’ (81.1 %), ‘Maternal mental health problems’ (10.3 %), ‘Maternal mental health problems and physical abuse’ (6.3 %) and ‘Parental conflict, mental health problems and emotional abuse’ (2.4 %). Parental separation/divorce was associated with higher IL-6. Parental alcohol problems, paternal mental health problems, parental convictions and emotional abuse were associated with lower levels of IL-6. Associations for paternal mental health problems and emotional abuse were only observed for boys. ACE score and LCA-derived ACE classes were not associated with differences in IL-6. Girls in the ‘Maternal mental health problems’ cluster had lower CRP levels. Specific adversities and adversity combinations are important for differences in childhood inflammation. Some associations were only observed for girls or boys.
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