Beta spectral power during sleep is associated with impaired recall of extinguished fear.
Beta spectral power during sleep is associated with impaired recall of extinguished fear.
复制标题
睡眠过程中的β光谱力与避免恐惧的回忆有关。
作者：
无法保留对已消除的恐惧的记忆在维持创伤后应激障碍（PTSD）中起着重要作用，成功的消退回忆是减轻症状所必需的。睡眠障碍是PTSD的标志性症状，会损害恐惧消退记忆。然而，我们对睡眠在消退保持中的作用的电生理机制的理解仍然不确定。我们研究了健康人（n = 71，包括男性和女性）和PTSD患者（n = 12）的初步研究中睡眠的微结构和消退回忆之间的关系。 参与者在2天内接受了恐惧条件反射和消退方案，在条件反射和消退之间进行睡眠记录。在消退学习24小时后，参与者进行了消退回忆。功率谱密度（PSD）计算前和后消光学习睡眠。在健康受试者中，消退前学习睡眠期间β波段PSD（~17-26 Hz）的增加与消退记忆较差相关（r = 0.41，p =.004）。 β PSD在三个晚上的睡眠中高度稳定（组内相关系数> 0.92）。 结果表明，β-波段PSD是特别牵连的困难回忆熄灭的恐惧。
The failure to retain memory for extinguished fear plays a major role in the maintenance of posttraumatic stress disorder (PTSD), with successful extinction recall necessary for symptom reduction. Disturbed sleep, a hallmark symptom of PTSD, impairs fear extinction recall. However, our understanding of the electrophysiological mechanisms underpinning sleep’s role in extinction retention remains underdetermined. We examined the relationship between the microarchitecture of sleep and extinction recall in healthy humans (n = 71, both male and females included) and a pilot study in individuals with PTSD (n = 12). Participants underwent a fear conditioning and extinction protocol over 2 days, with sleep recording occurring between conditioning and extinction. Twenty-four hours after extinction learning, participants underwent extinction recall. Power spectral density (PSD) was computed for pre- and post-extinction learning sleep. Increased beta-band PSD (~17–26 Hz) during pre-extinction learning sleep was associated with worse extinction recall in healthy participants (r = 0.41, p = .004). Beta PSD was highly stable across three nights of sleep (intraclass correlation coefficients > 0.92). Results suggest beta-band PSD is specifically implicated in difficulties recalling extinguished fear.
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影响因子：
3.4
作者：
Davidson P;Jönsson P;Carlsson I;Pace-Schott E
通讯作者：
Pace-Schott E
影响因子：
5.7
作者：
De Gennaro, L;Ferrara, M;Bertini, M
通讯作者：
Bertini, M
DOI：
10.1176/appi.ajp.2012.12040432
发表时间：
2013-04
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Germain A
通讯作者：
Germain A
影响因子：
2
作者：
Cowdin, Nancy;Kobayashi, Ihori;Mellman, Thomas A.
通讯作者：
Mellman, Thomas A.
慢波睡眠期间条件刺激暴露对人类恐惧记忆消退的影响
影响因子：
5.6
作者：
He, Jia;Sun, Hong-Qiang;Lu, Lin
通讯作者：
Lu, Lin