Plasma chromogranin A + B, neuropeptide Y and catecholamines in pheochromocytoma patients
Plasma chromogranin A + B, neuropeptide Y and catecholamines in pheochromocytoma patients
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嗜铬细胞瘤患者血浆嗜铬粒蛋白 A B、神经肽 Y 和儿茶酚胺
DOI：
10.1111/j.1365-2796.1991.tb00374.x
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发表时间：
1991
影响因子：
11.1
通讯作者：
E. Theodorsson
中科院分区：
文献类型：
--
作者：
S. Gröndal;B. Eriksson;B. Hamberger;E. Theodorsson
抽象。分析了7例嗜铬细胞瘤患者手术前、中、后血浆嗜铬粒蛋白A + B、神经肽Y和儿茶酚胺的水平。本研究的目的是确定这些血浆胺和肽的诊断灵敏度，并调查其围手术期波动。所有患者术前血浆嗜铬粒蛋白A + B均升高，术中无显著升高，术后恢复正常。神经肽Y，单独可以诱导高血压，存在于高水平的血浆中，从3名患者术前，进一步增加在手术过程中的4名患者，并在术后低的所有患者。5例患者术前血浆儿茶酚胺分级升高，所有患者在肿瘤切除过程中升高，术后恢复正常。可以得出结论，血浆嗜铬粒蛋白A + B表现出高的敏感性，嗜铬细胞瘤的分级尿儿茶酚胺的患者研究。
Abstract. Plasma levels of chromogranin A + B, neuropeptide Y and catecholamines were analysed before, during and after surgery in seven patients with pheochromocytoma. The aim of the study was to determine the diagnostic sensitivity of these plasma amines and peptides, and to investigate their peroperative fluctuations. Chromogranin A + B in plasma was increased preoperatively in all patients, showed no significant increase during surgery, and normalized postoperatively. Neuropeptide Y, which alone can induce hypertension, was present in high levels in plasma from three patients preoperatively, increased further in four patients during surgery, and was postoperatively low in all patients. Fractionated plasma catecholamines were increased in five patients before surgery, increased in all patients during tumour dissection, and normalized postoperatively. It may be concluded that plasma chromogranin A + B exhibited as high a sensitivity for pheochromocytoma as fractionated urinary catecholamines in the patients studied.
影响因子：
158.5
作者：
OCONNOR, DT;BERNSTEIN, KN
通讯作者：
BERNSTEIN, KN
影响因子：
158.5
作者：
OCONNOR, DT;DEFTOS, LJ
通讯作者：
DEFTOS, LJ