Stages of ciliogenesis and regulation of ciliary length.
Stages of ciliogenesis and regulation of ciliary length.
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DOI：
10.1016/j.diff.2011.11.015
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发表时间：
2012-02
期刊：
影响因子：
2.9
通讯作者：
Marshall, Wallace F.
中科院分区：
文献类型：
--
作者：
Avasthi, Prachee;Marshall, Wallace F.
纤毛和鞭毛是高度保守的真核细胞微管为基础的细胞器，突出于大多数哺乳动物细胞的表面。这些结构需要大的蛋白质复合物和马达用于微管蛋白的远端添加和睫状膜的延伸。为了使纤毛发生，必须协调许多过程。细胞周期调控、囊泡运输和纤毛延伸的复杂过程必须在精确的时间内完成，才能产生纤毛。在这里，我们回顾了纤毛发生的各个阶段以及组装纤毛长度的调节。细胞周期进程中纤毛发生的调节中心在中心粒，纤毛从中心粒延伸成熟成基体。中心粒成熟涉及从细胞分裂中的角色到纤毛成核的转变，通过迁移到细胞表面和对接在质膜上。对接依赖于由母中心粒获得的称为远端附属物的各种蛋白质结构。通过鞭毛内运输（IFT）的过程延长纤毛。纤毛结构的直接修饰以及信号转导通路的调节在纤毛的维持中起作用。所有这些阶段都受到严格的调节，以便在正确的时间产生正确大小的纤毛。最后，我们讨论了异常纤毛发生和纤毛长度控制在人类疾病中的意义以及一些悬而未决的问题。
Cilia and flagella are highly conserved eukaryotic microtubule-based organelles that protrude from the surface of most mammalian cells. These structures require large protein complexes and motors for distal addition of tubulin and extension of the ciliary membrane. In order for ciliogenesis to occur, coordination of many processes must take place. An intricate concert of cell cycle regulation, vesicular trafficking, and ciliary extension must all play out with accurate timing to produce a cilium. Here, we review the stages of ciliogenesis as well as regulation of the length of the assembled cilium. Regulation of ciliogenesis during cell cycle progression centers on centrioles, from which cilia extend upon maturation into basal bodies. Centriole maturation involves a shift from roles in cell division to cilium nucleation via migration to the cell surface and docking at the plasma membrane. Docking is dependent on a variety of proteinaceous structures, termed distal appendages, acquired by the mother centriole. Ciliary elongation by the process of intraflagellar transport (IFT) ensues. Direct modification of ciliary structures, as well as modulation of signal transduction pathways, play a role in maintenance of the cilium. All of these stages are tightly regulated to produce a cilium of the right size at the right time. Finally, we discuss the implications of abnormal ciliogenesis and ciliary length control in human disease as well as some open questions.
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影响因子：
7.8
作者：
Anderson, R G
通讯作者：
Anderson, R G
影响因子：
11.8
作者：
Bershteyn, Marina;Atwood, Scott X.;Woo, Wei-Meng;Li, Mischa;Oro, Anthony E.
通讯作者：
Oro, Anthony E.
影响因子：
3.5
作者：
Bowers, AJ;Boylan, JF
通讯作者：
Boylan, JF
DOI：
10.1083/jcb.200404024
发表时间：
2004-09-13
期刊：
The Journal of cell biology
影响因子：
--
作者：
Clarke DM;Brown MC;LaLonde DP;Turner CE
通讯作者：
Turner CE
DOI：
10.1083/jcb.141.4.993
发表时间：
1998-05-18
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cole DG;Diener DR;Himelblau AL;Beech PL;Fuster JC;Rosenbaum JL
通讯作者：
Rosenbaum JL