Atrophy and Intramuscular Fat in Specific Muscles of the Thigh
Atrophy and Intramuscular Fat in Specific Muscles of the Thigh
复制标题
大腿特定肌肉的萎缩和肌内脂肪
DOI：
--
复制
发表时间：
2011
影响因子：
4.2
通讯作者：
F. Ivey
中科院分区：
文献类型：
--
作者：
A. Ryan;A. Buscemi;L. Forrester;C. Hafer;F. Ivey
目的。肌少症和肌肉脂肪浸润增加可能在中风患者的功能损害和糖尿病的高风险中起作用。我们的目的是比较中风患者麻痹性和非麻痹性大腿6块肌肉的肌肉体积和肌肉衰减，并检查肌内脂肪和胰岛素抵抗之间的关系，以及肌肉体积和力量之间的关系。方法。年龄在40 - 84岁，BMI = 16 - 45 kg/m2的中风参与者（70人，男39人，女31人）接受了多次大腿CT扫描、DXA（双能x线吸收仪）全身扫描、峰值摄氧量（vo2峰值）分级跑步机测试、6分钟步行、空腹抽血和等速力量测试。结果。与非麻痹性大腿相比，麻痹性大腿的肌肉体积减少24%，皮下脂肪体积增加5%。非麻痹性大腿中部的肌肉衰减（肌肉脂肪浸润量指数）比麻痹性大腿中部高17%。半腱膜挛缩/半膜挛缩、股二头肌、缝阔肌、股内肌/股外侧肌和股直肌的肌肉面积比非瘫瘫的大腿小（9% - 19%）。6块肌肉中有5块的非麻痹侧肌肉衰减比麻痹侧高15% - 25%。非麻痹性大腿中部肌肉衰减与胰岛素呈负相关。非瘫腿和瘫腿的偏心峰值扭矩与相应的肌肉体积有关。结论。慢性中风患者骨骼肌萎缩、肌肉周围和肌肉内脂肪增加以及随之而来的肌肉无力与糖尿病风险有关，并可能损害功能活动能力和独立性。
Purpose. Sarcopenia and increased fat infiltration in muscle may play a role in the functional impairment and high risk for diabetes in stroke. Our purpose was to compare muscle volume and muscle attenuation across 6 muscles of the paretic and nonparetic thigh and examine the relationships between intramuscular fat and insulin resistance and between muscle volume and strength in stroke patients. Methods. Stroke participants (70; 39 men, 31 women) aged 40 to 84 years, BMI = 16 to 45 kg/m2 underwent multiple thigh CT scans, total body scan by DXA (dual-energy X-ray absorptiometry), peak oxygen intake (VO2peak) graded treadmill test, 6-minute walk, fasting blood draws, and isokinetic strength testing. Results. Muscle volume is 24% lower and subcutaneous fat volume is 5% higher in the paretic versus nonparetic thigh. Muscle attenuation (index of amount of fat infiltration in muscle) is 17% higher in the nonparetic midthigh than the paretic. The semitendinosis/semimembranosis, biceps femoris, sartorius, vastus (medialis/lateralis), and rectus femoris have lower (between 9% and 19%) muscle areas on the paretic than the nonparetic thigh. Muscle attenuation is 15% to 25% higher on the nonparetic than the paretic side for 5 of 6 muscles. The nonparetic midthigh muscle attenuation is negatively associated with insulin. Eccentric peak torque of the nonparetic leg and paretic leg are associated with the corresponding muscle volume. Conclusions. The skeletal muscle atrophy, increased fat around and within muscle, and ensuing muscular weakness observed in chronic stroke patients relates to diabetes risk and may impair functional mobility and independence.
影响因子：
16.2
作者：
Folsom, AR;Rasmussen, ML;Heiss, G
通讯作者：
Heiss, G
影响因子：
4.3
作者：
Ryan, AS;Dobrovolny, CL;Macko, RF
通讯作者：
Macko, RF