Temporal Changes in Infarct Material Properties: An In Vivo Assessment Using Magnetic Resonance Imaging and Finite Element Simulations.
Temporal Changes in Infarct Material Properties: An In Vivo Assessment Using Magnetic Resonance Imaging and Finite Element Simulations.
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DOI：
10.1016/j.athoracsur.2015.03.015
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Wenk JF
中科院分区：
文献类型：
--
作者：
McGarvey JR;Mojsejenko D;Dorsey SM;Nikou A;Burdick JA;Gorman JH 3rd;Jackson BM;Pilla JJ;Gorman RC;Wenk JF
Infarct expansion initiates and sustains adverse left ventricular (LV) remodeling after myocardial infarction (MI) and is influenced by temporal changes in infarct material properties. Data from ex vivo biaxial extension testing support this hypothesis; however, infarct material properties have never been measured in vivo. The goal of the current study was to serially quantify the in vivo material properties and fiber orientation of infarcted myocardium over a 12-week period in a porcine model of MI. A combination of magnetic resonance imaging (MRI), catheterization, finite element modeling, and numeric optimization was used to analyze posterolateral MI. Specifically, properties were determined by minimizing the difference between in vivo strains and volume calculated from MRI and strains and volume predicted by finite element modeling. In 1 week after MI, the infarct region was found to be approximately 20 times stiffer than normal diastolic myocardium. Over the course of 12 weeks, the infarct region became progressively less stiff as the LV dilated and ejection fraction decreased. The infarct thinned by nearly half during the remodeling period, and infarct fiber angles became more circumferentially oriented. The results reported here are consistent with previously described ex vivo biaxial extension studies of infarct material properties and the circumferential change of collagen orientation in posterolateral infarcts. The current study represents a significant advance in that the method used allows for the serial assessment of an individual infarct in vivo over time and avoids the inherent limitations related to the testing of excised tissues.
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DOI：
10.1186/1532-429x-14-70
发表时间：
2012-10-12
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Mekkaoui C;Huang S;Chen HH;Dai G;Reese TG;Kostis WJ;Thiagalingam A;Maurovich-Horvat P;Ruskin JN;Hoffmann U;Jackowski MP;Sosnovik DE
通讯作者：
Sosnovik DE
DOI：
10.1186/1532-429x-12-19
发表时间：
2010-03-30
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Xu C;Pilla JJ;Isaac G;Gorman JH 3rd;Blom AS;Gorman RC;Ling Z;Dougherty L
通讯作者：
Dougherty L
DOI：
10.1007/s12265-010-9244-0
发表时间：
2011-02-01
影响因子：
3.4
作者：
Gorman, Robert C.;Jackson, Benjamin M.;Gorman, Joseph H.
通讯作者：
Gorman, Joseph H.
影响因子：
5
作者：
Fomovsky GM;Rouillard AD;Holmes JW
通讯作者：
Holmes JW
DOI：
10.1115/1.4003438
发表时间：
2011-04
期刊：
Journal of biomechanical engineering
影响因子：
--
作者：
Wenk JF;Sun K;Zhang Z;Soleimani M;Ge L;Saloner D;Wallace AW;Ratcliffe MB;Guccione JM
通讯作者：
Guccione JM