Regional left ventricular myocardial contractility and stress in a finite element model of posterobasal myocardial infarction.
Regional left ventricular myocardial contractility and stress in a finite element model of posterobasal myocardial infarction.
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DOI：
10.1115/1.4003438
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Guccione JM
中科院分区：
文献类型：
--
作者：
Wenk JF;Sun K;Zhang Z;Soleimani M;Ge L;Saloner D;Wallace AW;Ratcliffe MB;Guccione JM
最近，一种非侵入性的方法来确定区域心肌收缩力，使用动物特定的有限元（FE）模型为基础的优化，被开发来研究羊与前心尖梗死。使用在以前的研究中开发的方法，其中包括标记的磁共振图像（MRI），三维（3D）心肌应变，左心室（LV）容量，左心室心导管压力，局部心肌收缩力和应力分布的羊后基底梗死进行了研究。使用先前开发的优化方案，通过最小化FE模型预测和实验测量的收缩应变和LV体积之间的误差，估计邻近梗死的非梗死边界区（BZ）心肌（Tmax_B）、远离梗死的心肌（Tmax_R）和梗死（Tmax_I）中的活性材料参数。发现优化的Tmax_B相对于Tmax_R显著降低，而发现Tmax_I为零。发现BZ中的肌纤维应力相对于远端区域升高。这可能会对收缩的肌细胞造成进一步的损害，导致心力衰竭。
Recently, a non-invasive method for determining regional myocardial contractility, using an animal-specific finite element (FE) model-based optimization, was developed to study sheep with anteroapical infarction. Using the methodology developed in the previous study, which incorporates tagged magnetic resonance images (MRI), three-dimensional (3D) myocardial strains, left ventricular (LV) volumes, and LV cardiac catheterization pressures, the regional myocardial contractility and stress distribution of a sheep with posterobasal infarction was investigated. Active material parameters in the noninfarcted borderzone (BZ) myocardium adjacent to the infarct (Tmax_B), in the myocardium remote from the infarct (Tmax_R), and in the infarct (Tmax_I) were estimated by minimizing the errors between FE model-predicted and experimentally measured systolic strains and LV volumes using the previously developed optimization scheme. The optimized Tmax_B was found to be significantly depressed relative to Tmax_R, while Tmax_I was found to be zero. The myofiber stress in the BZ was found to be elevated, relative to the remote region. This could cause further damage to the contracting myocytes, leading to heart failure.
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影响因子：
4.6
作者：
Wenk, Jonathan F.;Zhang, Zhihong;Cheng, Guangming;Malhotra, Deepak;Acevedo-Bolton, Gabriel;Burger, Mike;Suzuki, Takamaro;Saloner, David A.;Wallace, Arthur W.;Guccione, Julius M.;Ratcliffe, Mark B.
通讯作者：
Ratcliffe, Mark B.
DOI：
10.1016/j.jtcvs.2005.07.065
发表时间：
2006-03-01
影响因子：
6
作者：
Guccione, JM;Walker, JC;Ratcliffe, MB
通讯作者：
Ratcliffe, MB
影响因子：
1.8
作者：
Guttman, MA;Zerhouni, EA;McVeigh, ER
通讯作者：
McVeigh, ER
影响因子：
37.8
作者：
Moustakidis, P;Maniar, HS;Pasque, MK
通讯作者：
Pasque, MK
影响因子：
3.4
作者：
TOZEREN, A
通讯作者：
TOZEREN, A