Sepsis, complement and the dysregulated inflammatory response.
Sepsis, complement and the dysregulated inflammatory response.
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DOI：
10.1111/j.1582-4934.2009.00893.x
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发表时间：
2009-10
影响因子：
5.3
通讯作者：
Gao H
中科院分区：
文献类型：
--
作者：
Ward PA;Gao H
脓毒症是一个涉及多个个体且死亡率高的重大问题。除了已被批准用于治疗脓毒症患者的单一药物（重组活化蛋白C）外，支持性措施代表了主要的临床方法。有许多实验性脓毒症模型，主要在啮齿动物中。一种常用的模型是盲肠结扎穿孔（CLP）。在该模型中，补体的稳健活化与多种不同器官（肺、肾、肝、心脏）中C5a受体（C5aR、C5L2）的上调一起发生。在脓毒症患者中，存在补体激活的充分证据。在CLP模型中拦截C5a或其受体大大提高了脓毒症啮齿动物的存活率。有令人信服的证据表明，CLP引起强烈的促炎状态，C5a与其受体的相互作用可能与淋巴系统和肾上腺髓质细胞的凋亡、血液中性粒细胞先天免疫功能的丧失、消耗性凝血病和心脏功能障碍有关。这些发现可能对脓毒症患者的治疗干预具有意义。
Sepsis in human beings is a major problem involving many individuals and with a high death rate. Except for a single drug (recombinant activated protein C) that has been approved for treatment of septic patients, supportive measures represent the main clinical approach. There are many models of experimental sepsis, mostly in rodents. A commonly used model is cecal ligation and puncture (CLP). In this model, robust activation of complement occurs together with up-regulation of C5a receptors (C5aR, C5L2) in a variety of different organs (lungs, kidneys, liver, heart). In septic human beings there is abundant evidence for complement activation. Interception of C5a or its receptors in the CLP model greatly improves survival in septic rodents. There is compelling evidence that CLP causes an intense pro-inflammatory state and that C5a interaction with its receptors can be linked to apoptosis of the lymphoid system and cells of the adrenal medulla, loss of innate immune functions of blood neutrophils, consumptive coagulopathy and cardiac dysfunction. These findings may have implications for therapeutic interventions in human beings with sepsis.
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补体过敏毒素C5A在实验性败血症过程中诱导肾上腺囊肿细胞的凋亡。
影响因子：
3.7
作者：
Flierl, Michael A.;Rittirsch, Daniel;Chen, Anthony J.;Nadeau, Brian A.;Day, Danielle E.;Sarma, J. Vidya;Huber-Lang, Markus S.;Ward, Peter A.
通讯作者：
Ward, Peter A.
影响因子：
120.7
作者：
BRUNBUISSON, C;DOYON, F;REGNIER, B
通讯作者：
REGNIER, B
影响因子：
15.9
作者：
Guo, RF;Huber-Lang, M;Ward, PA
通讯作者：
Ward, PA
DOI：
10.1084/jem.20051207
发表时间：
2006-01-23
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Niederbichler AD;Hoesel LM;Westfall MV;Gao H;Ipaktchi KR;Sun L;Zetoune FS;Su GL;Arbabi S;Sarma JV;Wang SC;Hemmila MR;Ward PA
通讯作者：
Ward PA
影响因子：
4.8
作者：
Gao, HW;Neff, TA;Ward, PA
通讯作者：
Ward, PA