2011-12 seasonal influenza vaccines effectiveness against confirmed A(H3N2) influenza hospitalisation: pooled analysis from a European network of hospitals. A pilot study.
2011-12 seasonal influenza vaccines effectiveness against confirmed A(H3N2) influenza hospitalisation: pooled analysis from a European network of hospitals. A pilot study.
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DOI：
10.1371/journal.pone.0059681
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Moren A
中科院分区：
文献类型：
--
作者：
Rondy M;Puig-Barbera J;Launay O;Duval X;Castilla J;Guevara M;Costanzo S;de Gaetano Donati K;Moren A
流感疫苗接种战略旨在保护高危人群免受严重后果的影响。评估针对流感相关住院的季节性疫苗的有效性对于指导这些策略很重要。需要大样本量才能准确估计流感疫苗针对严重后果的有效性(IVE)。我们通过一个由欧盟21家医院组成的网络，评估了将季节性IVE与实验室确诊的流感住院情况进行比较的可行性。我们在法国(七家医院)、意大利(一家医院)以及西班牙的纳瓦拉(四家医院)和巴伦西亚(九家医院)地区进行了一项多中心研究。所有在≥住院18年、在7天内出现流感样疾病的患者都被拭子擦拭。6例患者为甲型H3N1流感RT-PCR阳性患者；对照组为任何流感病毒阴性患者。采用Logistic回归将研究部位作为固定效应，计算出调整了潜在混杂因素后的I值。我们只对那些在四天内拭子的进行了分析。我们包括375例甲型H3N1流感病例和770例对照。整体调整后的IVE为24.9%(95%CI-1.8；44.6)。在接种目标人群(N = 1058)中，调整后的IVE分别为28.8%(95%CI：2.8；47.9)、36.8%(95%CI：−48.8；73.1)、42.6%(95%CI：−16.5；71.7)、17.8%(95%CI：−40.8；52.1)和37.5%(95%CI：−22.8；年龄18~、65~74岁、75~84岁及84岁以上。基于汇集通过欧洲医院网络获得的数据来估计IVE是可行的。我们的结果表明，2011-12年度住院确诊流感的IVE较低。低IVE可能是由于高危人群免疫反应较差、疫苗与循环毒株不完全匹配或由于季节较晚而免疫力减弱所致。在这个网络中增加样本量将使人们能够根据接种疫苗和疫苗类型或品牌以来的时间对IVE进行更准确的估计和分层。
Influenza vaccination strategies aim at protecting high-risk population from severe outcomes. Estimating the effectiveness of seasonal vaccines against influenza related hospitalisation is important to guide these strategies. Large sample size is needed to have precise estimate of influenza vaccine effectiveness (IVE) against severe outcomes. We assessed the feasibility of measuring seasonal IVE against hospitalisation with laboratory confirmed influenza through a network of 21 hospitals in the European Union. We conducted a multicentre study in France (seven hospitals), Italy (one hospital), and Navarra (four hospitals) and Valencia (nine hospitals) regions in Spain. All ≥18 years hospitalised patients presenting an influenza-like illness within seven days were swabbed. Cases were patients RT-PCR positive for influenza A (H3N2); controls were patients negative for any influenza virus. Using logistic regression with study site as a fixed effect we calculated IVE adjusted for potential confounders. We restricted the analyses to those swabbed within four days. We included, 375 A(H3N2) cases and 770 controls. The overall adjusted IVE was 24.9% (95%CI–1.8;44.6). Among the target group for vaccination (N = 1058) the adjusted IVE was 28.8% (95%CI:2.8;47.9); it was respectively 36.8% (95%CI:−48.8; 73.1), 42.6% (95%CI:−16.5;71.7), 17.8%(95%CI:−40.8; 52.1) and 37.5% (95%CI:−22.8;68.2) in the age groups 18–64, 65–74, 75–84 and more than 84 years. Estimation of IVE based on the pooling of data obtained through a European network of hospitals was feasible. Our results suggest a low IVE against hospitalised confirmed influenza in 2011–12. The low IVE may be explained by a poor immune response in the high-risk population, imperfect match between vaccine and circulating strain or waning immunity due to a late season. Increased sample size within this network would allow more precise estimates and stratification of the IVE by time since vaccination and vaccine types or brands.
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影响因子：
7
作者：
Huedo-Medina, Tania B.;Sanchez-Meca, Julio;Botella, Juan
通讯作者：
Botella, Juan
影响因子：
4.5
作者：
Leekha, Surbhi;Zitterkopf, Nicole L.;Sampathkumar, Priya
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Sampathkumar, Priya
影响因子：
5.5
作者：
Hardelid, Pia;Fleming, Douglas M.;Pebody, Richard
通讯作者：
Pebody, Richard
影响因子：
3.7
作者：
Kissling, Esther;Valenciano, Marta;Moren, Alain
通讯作者：
Moren, Alain
影响因子：
6.4
作者：
Buxton, JA;Skowronski, DM;Hockin, J
通讯作者：
Hockin, J