An efficient full space-time discretization method for subject-specific hemodynamic simulations of cerebral arterial blood flow with distensible wall mechanics.
An efficient full space-time discretization method for subject-specific hemodynamic simulations of cerebral arterial blood flow with distensible wall mechanics.
复制标题
一种有效的全时空离散方法,用于利用可扩张壁力学对脑动脉血流进行特定受试者的血流动力学模拟。
DOI:
10.1016/j.jbiomech.2019.02.014
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发表时间:
2019
影响因子:
2.7
通讯作者:
C Park, A Alaraj
中科院分区:
文献类型:
--
作者:
C Park, A Alaraj
A computationally inexpensive mathematical solution approach using orthogonal collocations for space discretization with temporal Fourier series is proposed to compute subject-specific blood flow in distensible vessels of large cerebral arterial networks. Several models of wall biomechanics were considered to assess their impact on hemodynamic predictions. Simulations were validated againstin vivoblood flow measurements in six human subjects. The average root-mean-square relative differences were found to be less than 4.3% for all subjects with a linear elastic wall model. This discrepancy decreased further in a viscoelastic Kelvin-Voigt biomechanical wall. The results provide support for the use of collocation-Fourier series approach to predict clinically relevant blood flow distribution and collateral blood supply in large portions of the cerebral circulation at reasonable computational costs. It thus opens the possibility of performing computationally inexpensive subject-specific simulations that are robust and fast enough to predict clinical results in real time on the same day.
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影响因子:
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作者:
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DOI:
--
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期刊:
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