North American Prodrome Longitudinal Study (NAPLS 2): overview and recruitment.
North American Prodrome Longitudinal Study (NAPLS 2): overview and recruitment.
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DOI：
10.1016/j.schres.2012.09.012
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发表时间：
2012-12
影响因子：
4.5
通讯作者：
Cannon TD
中科院分区：
文献类型：
--
作者：
Addington J;Cadenhead KS;Cornblatt BA;Mathalon DH;McGlashan TH;Perkins DO;Seidman LJ;Tsuang MT;Walker EF;Woods SW;Addington JA;Cannon TD
北美前驱症状纵向研究（NAPLS）是一个由八个项目组成的联盟，专注于精神病前驱症状。由国家精神卫生研究所（NIMH）资助，这些网站位于埃默里大学，哈佛大学，卡尔加里大学，加州大学洛杉矶分校，加州大学圣地亚哥分校，北卡罗来纳州查佩尔山大学，耶鲁大学和朱克希尔赛德医院。虽然这些项目最初是独立开发的，但他们之前曾合作将其历史数据集联合收割机结合起来，并在全球最大的纵向跟踪前驱受试者样本中对精神病的预测因素进行了一系列分析。这导致了一项为期五年的前瞻性研究“转化为精神病的预测因素和机制”的发展，（也称为NAPLS-2），有三个主要目标：（1）前瞻性地测试NAPLS-1中开发的预测算法，（2）研究可能有助于精神病发展的神经解剖学、神经生理学、神经认知和神经激素因素，和（3）开发来自符合临床高风险（HRM）状态诊断标准的参与者和来自人口统计学上相似的健康受试者的DNA、RNA和血浆的储存库。由NIMH在2008年资助，NAPLS-2将产生最大的精神病样本，有720名精神病患者和240名健康对照受试者，因此将提供任何单一地点研究都无法复制的统计能力和科学范围。本文描述了NAPLS-2项目的总体方法，并报告了研究（360例）和180例对照的中间点的确定和人口统计学。
The North American Prodrome Longitudinal Study (NAPLS) is a consortium of eight programs focusing on the psychosis prodrome. Funded by the National Institute of Mental Health (NIMH), the sites are located at Emory University, Harvard University, University of Calgary, UCLA, UCSD, University of North Carolina Chapel Hill, Yale University, and Zucker Hillside Hospital. Although the programs initially developed independently, they previously collaborated to combine their historical datasets and to produce a series of analyses on predictors of psychosis in one of the largest samples of longitudinally followed prodromal subjects worldwide. This led to the development of a five year prospective study “Predictors and Mechanisms of Conversion to Psychosis”, (also known as NAPLS-2) with three major aims: (1) to prospectively test the prediction algorithm developed in NAPLS-1, (2) to investigate the neuroanatomical, neurophysiological, neurocognitive, and neurohormonal factors that may contribute to the development of psychosis, and (3) to develop a repository of DNA, RNA, and plasma from participants meeting diagnostic criteria for a clinical high risk (CHR) state and from demographically similar healthy subjects. Funded by NIMH in 2008, NAPLS-2 will generate the largest CHR for psychosis sample with 720 CHR and 240 healthy comparison subjects, and thus will provide statistical power and scientific scope that cannot be duplicated by any single site study. This paper describes the overall methodology of the NAPLS-2 project and reports on the ascertainment and demographics at the midway point of the study with (360 CHR) and 180 controls.
影响因子：
6.6
作者：
Addington, Jean;Cadenhead, Kristin S.;Heinssen, Robert
通讯作者：
Heinssen, Robert
影响因子：
--
作者：
McGlashan, TH;Hoffman, RE
通讯作者：
Hoffman, RE
影响因子：
--
作者：
Cannon, Tyrone D.;Cadenhead, Kristin;Heinssen, Robert
通讯作者：
Heinssen, Robert