Carbohydrates as Drugs
Carbohydrates as Drugs
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碳水化合物作为药物
DOI：
10.1007/978-3-319-08675-0
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Rademacher C (Eds.)
中科院分区：
文献类型：
--
作者：
Seeberger PH;Rademacher C (Eds.)
碳水化合物是最丰富的一类生物分子，自然界已经利用这些结构复杂的分子进行了许多应用。每个活细胞都被低聚糖覆盖，这有助于它们的稳定性，促进细胞间的交流，或控制细胞迁移和组织归巢。这种生物聚合物的多样性超过了任何其他有机结构。因此，糖基化相关基因的数量很高，大约有2%的人类基因组编码这些蛋白质。随着合成和分析聚糖的新工具越来越广泛，糖基化相关基因在健康和疾病中的作用开始被揭示。这些进步激发了人们对碳水化合物及其衍生物作为药物活性成分的兴趣，如碳水化合物结合或加工蛋白质的抑制剂，或新型佐剂和疫苗。然而，与聚糖治疗人类疾病的潜力相比，以碳水化合物为基础的药物的数量相当有限。事实上，每个糖苷键构成一个新的立体中心，使碳水化合物的合成具有挑战性。碳水化合物是亲水的，代谢不稳定，有时是混杂的，因为在许多情况下，低亲和力识别对它们的一些生物学功能是必不可少的。碳水化合物衍生物的高效合成途径使我们能够克服这些障碍。通过碳水化合物支架的进化，可以控制其稳定性和亲水性，并建立特异性。虽然单糖通常对其靶受体的亲和力较低，但由于其低分子量，它提供了高配体效率。此外，焓驱动的相互作用是基于定向相互作用，这是小分子进化的一个精致的起点。否则难以接近的结合位点可以处理不容纳扁平和芳香分子。本卷是由章节的集合解决的问题和潜力的碳水化合物作为药物从不同的角度。第一章描述了碳水化合物衍生物的靶向合成，特别强调了c -糖苷的合成以克服碳水化合物的代谢不稳定性。此外，作者探索多米诺骨牌碳水化合物转化为药物样支架。提高了v的合成可及性
Carbohydrates are the most abundant class of biomolecules and nature has made use of these structurally complex molecules for many applications. Every living cell is covered by oligosaccharides contributing to their stability, promoting cell–cell communication, or control cell migration and tissue homing. The diversity of this biopolymer exceeds that of any other organic structure. Consequently, the number of glycosylation-associated genes is high, with approximately 2% of the human genome encoding for these proteins. With novel tools for the synthesis and analysis of glycans becoming available to the broader community, the role of glycosylation-associated genes in health and disease is beginning to unravel. These advances have spurred increasing interest in carbohydrates and their derivatives as active ingredients in pharmaceuticals such as inhibitors of carbohydratebinding or-processing proteins, or novel adjuvants and vaccines. However, in contrast to the potential of glycans for the treatment of human disease, the number of carbohydrate-based drugs is rather limited. The fact that each glycosidic linkage constitutes a new stereogenic center renders the synthesis of carbohydrates challenging. Carbohydrates are hydrophilic, metabolically unstable and sometimes promiscuous, as in many cases low affinity recognition is essential for some of their biological functions. Efficient synthetic access to carbohydrate-derivatives enables us to overcome these obstacles. Stability and hydrophilicity can be controlled and specificity can be established by evolution of the carbohydrate scaffold. Although a monosaccharide often has a rather low affinity to its target receptor, it provides high ligand efficiency, because of its low molecular weight. Moreover, the enthalpy-driven interaction is based on directed interactions, an exquisite starting point for small molecule evolution. Otherwise inaccessible binding sites can addressed that do not accommodate flat and aromatic molecules. This volume is comprised of a collection of chapters addressing the problems and the potentials of carbohydrates as drugs from different perspectives. The opening chapter describes the target-oriented synthesis of carbohydrate-derivatives, in particular highlighting the synthesis of C-glycosides to overcome metabolic instability of carbohydrates. Moreover, the authors explore domino carbopalladation to transform carbohydrates into drug-like scaffolds. The improved synthetic accessibility of v
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海洋天然产物海藻毒素和C-糖苷及其母体糖苷的优选溶液构象
DOI：
--
发表时间：
1993
期刊：
影响因子：
--
作者：
Y. Kishi
通讯作者：
Y. Kishi
3-(1,2,3-三唑-1-基)-1-硫代半乳糖苷是半乳糖凝集素 3 的小型、高效且水解稳定的抑制剂。
影响因子：
2.7
作者：
B. Salameh;H. Leffler;U. Nilsson
通讯作者：
U. Nilsson
抗体和/或细胞介导的免疫，真菌疾病的保护机制：持续的困境还是不必要的争议？
DOI：
--
发表时间：
1998
期刊：
Medical mycology : official publication of the International Society for Human and Animal Mycology.
影响因子：
--
作者：
Casadevall,A;Cassone,A;Bistoni,F;Cutler,JE;Magliani,W;Murphy,JW;Polonelli,L;Romani,L
通讯作者：
Romani,L
DOI：
10.1152/ajprenal.1992.263.3.f459
发表时间：
1992-09
期刊：
The American journal of physiology
影响因子：
--
作者：
Rebecca G. Wells;A. Pajor;Y. Kanai;E. Turk;E. M. Wright;M. Hediger
通讯作者：
Rebecca G. Wells;A. Pajor;Y. Kanai;E. Turk;E. M. Wright;M. Hediger
影响因子：
3.1
作者：
Cartmell, Jonathan;Paszkiewicz, Eugenia;Bundle, David R.
通讯作者：
Bundle, David R.