Influenza (H5N1) viruses in poultry, Russian Federation, 2005-2006.
Influenza (H5N1) viruses in poultry, Russian Federation, 2005-2006.
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DOI：
10.3201/eid1304.061266
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发表时间：
2007-04
影响因子：
11.8
通讯作者：
Shestopalov AM
中科院分区：
文献类型：
--
作者：
Lipatov AS;Evseenko VA;Yen HL;Zaykovskaya AV;Durimanov AG;Zolotykh SI;Netesov SV;Drozdov IG;Onishchenko GG;Webster RG;Shestopalov AM
迁徙水禽可能是西伯利亚西部和俄罗斯联邦欧洲部分流感（H5N1）的主要来源。我们研究了2005年7月至2006年2月期间从西伯利亚西部和俄罗斯联邦欧洲部分的家禽中分离出的7种流感（H5N1）病毒。全基因组序列与青海H5N1亚型流感病毒有较高的同源性。系统发育分析不仅显示了家禽和野生迁徙水禽分离的H5N1毒株之间的密切遗传关系，但也建议分析分离株之间的遗传重配。推导的M2和神经氨酸酶蛋白质的氨基酸序列的分析表明，所有分离株是潜在的敏感，目前可用的抗病毒药物。致病性试验表明，所有研究的病毒在鸡中的高致病性，在小鼠和雪貂测试的3个分离物，致病性是异质性的。哺乳动物模型中的致病性通常与聚合酶碱性蛋白2残基627处的赖氨酸相关。
Migrating waterfowl may be the primary source of influenza (H5N1) in western Siberia and the European part of the Russian Federation. We studied 7 influenza (H5N1) viruses isolated from poultry in western Siberia and the European part of the Russian Federation during July 2005–February 2006. Full genome sequences showed high homology to Qinghai-like influenza (H5N1) viruses. Phylogenetic analysis not only showed a close genetic relationship between the H5N1 strains isolated from poultry and wild migratory waterfowls but also suggested genetic reassortment among the analyzed isolates. Analysis of deduced amino acid sequences of the M2 and neuraminidase proteins showed that all isolates are potentially sensitive to currently available antiviral drugs. Pathogenicity testing showed that all studied viruses were highly pathogenic in chickens; for 3 isolates tested in mice and 2 tested in ferrets, pathogenicity was heterogeneous. Pathogenicity in mammalian models was generally correlated with Lys at residue 627 of polymerase basic protein 2.
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影响因子：
168.9
作者：
Claas, ECJ;Osterhaus, ADME;Webster, RG
通讯作者：
Webster, RG
DOI：
10.1073/pnas.0507415102
发表时间：
2005-12-20
影响因子：
11.1
作者：
Gabriel, G;Dauber, B;Stech, J
通讯作者：
Stech, J
影响因子：
5.4
作者：
Govorkova, EA;Rehg, JE;Hoffmann, E
通讯作者：
Hoffmann, E
影响因子：
5.4
作者：
Maines, TR;Lu, XH;Tumpey, TM
通讯作者：
Tumpey, TM
影响因子：
3.8
作者：
Lipatov, AS;Andreansky, S;Sangster, MY
通讯作者：
Sangster, MY