Differential bone histomorphometric characters of the mandible in senescence-accelerated mice (SAMP6 and SAMP8): murine models for senile osteoporosis and temporomandibular joint osteoarthritis
Differential bone histomorphometric characters of the mandible in senescence-accelerated mice (SAMP6 and SAMP8): murine models for senile osteoporosis and temporomandibular joint osteoarthritis
复制标题
加速衰老小鼠（SAMP6和SAMP8）下颌骨的骨组织形态学特征：老年骨质疏松症和颞下颌关节骨关节炎的小鼠模型
DOI：
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Hironobu Sato
中科院分区：
文献类型：
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作者：
Y. Daigo;T. Matsuura;Hironobu Sato
用SAMP6作为老年性骨质疏松症(OP)模型，SAMP8作为TMJOA模型，SAMR1作为对照，对衰老加速小鼠(SAM)的下颌骨和股骨进行了组织形态计量学分析。选用2个月或4个月龄的雄性小鼠36只(每个品系和年龄各6只)。测量股骨远端干骺端和下颌升支包括牙槽骨的皮质厚度指数(CTI)、骨面积(B.Ar/T.Ar)、骨小梁宽度(Tb.Wi)、骨小梁数量(Tb.N)、骨小梁间距(Tb.Sp)、成骨细胞周长(N.Ob/B.Pm)和破骨细胞周长(N.Oc/B.Pm)。与SAMR1相比，SAMP6在2月龄和4月龄时股骨和下颌骨的B.Ar/T.Ar和Tb.Wi均较低。该品系在4月龄时表现出较低的骨骼CTI和较高的股骨Tb.N和Tb.Sp。SAMP8在2个月龄时显示出较高的CTI，在4个月龄时下颌骨保持较高的CTI指数，而股骨不保持较高的CTI指数，但骨量并未减少。SAMP6在4个月龄时股骨表现为较低的N.Ob/B.Pm，而在2、4个月龄时，SAMP8在下颌骨中表现为较低的N.Ob/B.Pm，但在股骨中不显示。不同SAM品系的下颌骨组织形态计量学特征的差异可能暗示了具有老年性OP和TMJOA遗传背景的SAM小鼠下颌骨性能的差异。
Histomorphometric analyses of the mandible and femur were performed in senescence-accelerated mice (SAM) using SAMP6 as a senile osteoporosis (OP) model, SAMP8 as a temporomandibular joint osteoarthritis (TMJOA) model, and SAMR1 as control. Thirty-six male mice at 2 or 4 months of age (6 for each strain and age) were used. The cortical thickness index (CTI), bone area (B.Ar/T.Ar), trabecular width (Tb.Wi), trabecular number (Tb.N), trabecular separation (Tb.Sp), osteoblast perimeter (N.Ob/B.Pm), and osteoclast perimeter (N.Oc/B.Pm) were assessed in the distal femoral metaphysis and in the mandibular ramus including the alveolar bone. Compared with SAMR1, SAMP6 showed lower B.Ar/T.Ar and Tb.Wi in the femur and mandible at 2 and 4 months of age. This strain showed lower CTI in both bones and higher Tb.N and Tb.Sp in the femur at 4 months of age. SAMP8 showed higher CTI in both bones at 2 months of age and maintained a high index in the mandible but not in the femur at 4 months of age; however trabecular bone mass was not reduced. SAMP6 exhibited lower N.Ob/B.Pm in the femur but not in the mandible at 4 months of age, while SAMP8 showed lower N.Oc/B.Pm in the mandible but not in the femur at 2 and 4 months of age. The differential histomorphometric features of the mandible in different SAM strains may imply a difference in mandibular bone property between SAM mice with senile OP and TMJOA genetic background.
影响因子：
4.3
作者：
Reinhardt, RA;Payne, JB;Mattson, JS
通讯作者：
Mattson, JS
影响因子：
15.9
作者：
Jilka, RL;Weinstein, RS;Manolagas, SC
通讯作者：
Manolagas, SC