Recent advances in drug eluting stents.
Recent advances in drug eluting stents.
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DOI：
10.1016/j.ijpharm.2012.10.029
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发表时间：
2013-01-30
影响因子：
5.8
通讯作者：
Peppas, Nicholas A.
中科院分区：
文献类型：
--
作者：
Puranik, Amey S.;Dawson, Eileen R.;Peppas, Nicholas A.
重新开放闭塞血管的最常见的医学干预措施之一是植入冠状动脉支架。虽然这种治疗方法最初是有效的，但动脉的再狭窄或再狭窄经常发生，主要是由于平滑肌细胞的新生内膜增生。药物洗脱支架的开发是为了提供局部的、部位特异性的、受控释放的药物，这些药物可以抑制新生内膜的形成。通过实施控释给药系统，有可能控制药理因子的时间释放，从而能够绕过与支架增生相关的一些关键事件，并防止后续干预的需要。然而，自从第一代药物洗脱支架问世以来，其长期的不良反应引起了人们对其安全性的担忧。这些在安全性和有效性方面的局限性引发了人们对开发可生物降解支架和更有效的药物输送系统的大量研究。在这篇综述中，我们阐明了药物洗脱支架的最新进展、相关问题，并重点介绍了这一领域正在进行的一些研究。
One of the most common medical interventions to reopen an occluded vessel is the implantation of a coronary stent. While this method of treatment is effective initially, restenosis, or the re-narrowing of the artery frequently occurs largely due to neointimal hyperplasia of smooth muscle cells. Drug eluting stents were developed in order to provide local, site-specific, controlled release of drugs that can inhibit neointima formation. By implementing a controlled release delivery system it may be possible to control the time release of the pharmacological factors and thus be able to bypass some of the critical events associated with stent hyperplasia and prevent the need for subsequent intervention. However, since the advent of first-generation drug eluting stents, long-term adverse effects have raised concerns regarding their safety. These limitations in safety and efficacy have triggered considerable research in developing biodegradable stents and more potent drug delivery systems. In this review, we shed light on the current state-of-the-art in drug eluting stents, problems related to them and highlight some of the ongoing research in this area.
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影响因子：
5.7
作者：
Bennett, MR
通讯作者：
Bennett, MR
DOI：
10.1073/pnas.87.13.5134
发表时间：
1990-07-01
影响因子：
11.1
作者：
CUSHING, SD;BERLINER, JA;FOGELMAN, AM
通讯作者：
FOGELMAN, AM
影响因子：
14
作者：
Chen, Mei-Chin;Chang, Yen;Sung, Hsing-Wen
通讯作者：
Sung, Hsing-Wen
影响因子：
14
作者：
Banai, S;Chorny, M;Golomb, G
通讯作者：
Golomb, G
影响因子：
5.3
作者：
FEIG, LA;PEPPAS, NA;LEES, RS
通讯作者：
LEES, RS