Correlation and Survival Analysis of Distant Metastasis Site and Prognosis in Patients With Hepatocellular Carcinoma.
Correlation and Survival Analysis of Distant Metastasis Site and Prognosis in Patients With Hepatocellular Carcinoma.
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DOI：
10.3389/fonc.2021.652768
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发表时间：
2021
影响因子：
4.7
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Zhan H;Zhao X;Lu Z;Yao Y;Zhang X
目的探讨肝细胞癌远处转移患者的预后因素及生存分析。从SEER数据库中提取2010~2015年间3126例肝细胞癌远处转移患者的临床资料，回顾分析肝癌远处转移部位与预后的关系。根据不同的转移部位将患者分组。临床特征比较采用卡方检验，生存曲线采用Kaplan-Meier法，单因素分析采用Log-ranch检验，多因素分析采用Cox回归。并使用倾向得分匹配(PSM)来减少基线特征的差异。PSM前，有肺转移的肝细胞癌患者的预后比无肺转移的患者差。有无骨转移无统计学差异，单器官转移患者预后好于多器官转移患者。在器官转移的患者中，骨转移的预后好于肺转移的患者。经PSM治疗后，有骨转移的肝癌患者的预后比无骨转移的患者差(P<；0.05)。单因素分析显示，肿瘤分化程度、T分期、N分期、原发灶及转移手术、放化疗、肿瘤大小、单器官转移、转移器官个数、转移器官组合与肝细胞癌远处转移患者的预后有关(P<；0.05)。多因素分析显示，年龄≥、52岁、男性、肿瘤分化程度低、N1分期、无一期手术、无放化疗、肿瘤大小<6 cm、多器官转移是转移性肝细胞癌预后不良的独立影响因素。肺是肝细胞癌最常见的远处转移部位。单器官转移预后好于多器官转移。年龄≥，52岁，男性，肿瘤分化程度低，N1分期，无一次手术，无放化疗，肿瘤大小<6 cm，多器官转移是转移性肝细胞癌患者总体生存率和肿瘤特异性生存预后差的独立影响因素。
To investigate the prognostic factors and survival analysis of patients with hepatocellular carcinoma with distant metastasis. The clinical data of 3,126 patients with distant metastasis of hepatocellular carcinoma from 2010 to 2015 were extracted from SEER database, and the correlation between the location of distant metastasis of hepatocellular carcinoma and prognosis was retrospectively analyzed. Patients were grouped according to different metastatic sites. The clinical characteristics of each group were compared by chi-square test, the survival curve was drawn by Kaplan-Meier method, Log-rank test was used for univariate analysis, and Cox regression for multivariate analysis. And use propensity score matching (PSM) to reduce differences in baseline characteristics. Before PSM, the prognosis of patients with hepatocellular carcinoma with lung metastasis is worse than that of patients without lung metastasis. And there was no statistically significant difference with or without bone metastases.Patients with one type of organ metastasis had better prognosis than those with multiple organ metastasis. Among patients with organ metastasis, bone metastasis has a better prognosis than patients with lung metastasis. After PSM, patients with HCC with bone metastases had a worse prognosis than those without bone metastases (P<0.05). Univariate analysis showed that the degree of tumor differentiation, T stage, N stage, primary tumor and metastatic surgery, radiotherapy and chemotherapy, tumor size, single organ metastasis, the number of metastatic organs, and the combination of metastatic organs were related to the prognosis of patients with distant metastasis of hepatocellular carcinoma (P < 0.05). Multiariate analysis showed that age ≥52 years old, male, low degree of tumor differentiation, N1 stage, no primary surgery, no chemoradiotherapy, tumor size > 6cm, and multi-organ metastasis were independent influencing factors for poor prognosis in patients with metastatic hepatocellular carcinoma. The lung is the most common site of distant metastasis of hepatocellular carcinoma. Single organ metastasis has better prognosis than multiple organ metastasis. Age ≥52 years old, male, low degree of tumor differentiation, N1 stage, no primary surgery, no chemoradiotherapy, tumor size > 6cm, and multi-organ metastasis were independent influencing factors for poor overall survival and cancer-specific survival prognosis in patients with metastatic hepatocellular carcinoma.
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影响因子：
3.8
作者：
Keutgen XM;Nilubol N;Glanville J;Sadowski SM;Liewehr DJ;Venzon DJ;Steinberg SM;Kebebew E
通讯作者：
Kebebew E
影响因子：
9.8
作者：
Welzel, Tania M.;Graubard, Barry I.;Quraishi, Sabah;Zeuzem, Stefan;Davila, Jessica A.;El-Serag, Hashem B.;McGlynn, Katherine A.
通讯作者：
McGlynn, Katherine A.
1990-2017年中国肝癌发病率和死亡率的长期趋势：连接点和年龄-时期-队列分析
DOI：
10.3390/ijerph16162878
发表时间：
2019-08-14
影响因子：
--
作者：
Wang, Fang;Mubarik, Sumaira;Li, Hao
通讯作者：
Li, Hao
影响因子：
5.3
作者：
Riihimaeki, M.;Hemminki, A.;Hemminki, K.
通讯作者：
Hemminki, K.
影响因子：
2.6
作者：
Mizuguchi, Shinjiro;Nishiyama, Noritoshi;Kubo, Shoji
通讯作者：
Kubo, Shoji